Intas Nayflee Plus Dual-Action Monthly Ectoparasiticide Spot-On for Cats & Kittens

Active Formulation Matrix & Pharmacological Actions

Active ConstituentConcentration (% w/v)Pharmacological ClassTarget Parasites & Biological Mode of ActionFipronil9.8% w/vPhenylpyrazole EctoparasiticideInhibits parasite GABA-gated chloride channels, causing uncontrolled neural hyperexcitation and death of Adult Fleas (Ctenocephalides felis), Ticks, and Lice.(S)-Methoprene11.8% w/vInsect Growth Regulator (IGR)Mimics juvenile hormones; prevents embryogenesis in Flea Eggs and halts pupation in Flea Larvae, breaking reproductive cycles.Spreading VehicleBase q.s. to 0.5 mlCutaneous Lipid ExcipientFacilitates rapid translocation across epidermal sebum and into sebaceous glands for sustained release.

Clinical Veterinary Indications

• Treatment, prevention, and control of adult flea infestations (Ctenocephalides felis).

• Prevention of flea egg hatching and larval development in the immediate home environment.

• Elimination and control of tick infestations (Rhipicephalus sanguineus, Ixodes ricinus, Haemaphysalis spp.).

• Treatment and control of biting lice (Felicola subrostratus).

• Essential therapeutic component in managing feline Flea Allergy Dermatitis (FAD).

• Adjunctive control in acral lick dermatitis complicated by parasite activity.

Comparison: Intas Nayflee Plus Cat vs. Frontline Plus Cat vs. Plain Fipronil Spot-Ons

Clinical ParameterIntas Nayflee Plus Cat (Current)Frontline Plus for CatsPlain Fipronil Spot-On (e.g., Fiprofort)Active IngredientsFipronil (9.8%) + (S)-Methoprene (11.8%)Fipronil (9.8%) + (S)-Methoprene (11.8%)Fipronil (9.8% w/v) aloneKills Adult Fleas & TicksYesYesYesBreaks Flea Life Cycle (IGR)Yes (Halts eggs & larvae)Yes (Halts eggs & larvae)No (Adult kill only)Environmental ProtectionHigh (Prevents home re-infestation)HighLow (Home eggs continue hatching)FAD Control EfficacySuperiorSuperiorModeratePricing TierValue-optimized for Indian pet parentsPremium imported tierEntry-level tier

Directions for Use & Step-by-Step Application Protocol

For external topical spot-on application only:

1. Packaging Removal: Take the 0.5ml plastic pipette out of its protective blister foil. Hold the pipette upright facing away from your face and snap or twist the applicator tip open.

2. Target Anatomical Site (Crucial): Identify the base of the skull at the back of the neck, between the shoulder blades. This is the one anatomical area your cat cannot reach to groom or lick.

3. Exposing the Skin: Part your cat's fur thoroughly until the bare skin is clearly visible.

4. Single-Spot Application: Place the tip of the pipette directly onto the exposed skin and squeeze firmly several times to empty the entire 0.5ml contents in one single spot. Do not split the dose across multiple areas.

5. Do Not Rub In: Allow the solution to absorb and spread naturally through epidermal oils. A temporary oily patch at the application site is normal and dries within 24 to 48 hours.

6. Post-Application Monitoring (30–60 Minutes): Keep your cat distracted or fit an Elizabethan collar (e-collar) for 30 to 60 minutes until dry. Ingestion from self-grooming may cause bitter-taste drooling (ptyalism).

7. Bathing Restriction: Keep the cat dry; do not bathe for 48 hours before or after application to allow the sebaceous lipid reservoir to establish.

8. Application Interval: Apply once every 4 weeks (monthly) for year-round protection, especially during warm and humid monsoon seasons.

Product Specifications

ParameterDetailsBrandIntas Pharmaceuticals Ltd. (Intas Animal Health - PET Division)Product Trade NameNayflee Plus Spot-On for CatsProduct ClassificationDual-Action Veterinary Ectoparasiticide & Insect Growth RegulatorActive CompositionFipronil (9.8% w/v) + (S)-Methoprene (11.8% w/v)Dosage FormCutaneous Topical Spot-On LiquidPack SizeSingle Pipette (0.5 ml unit dose)Target SpeciesCats and Kittens (8 weeks and older, up to 10 kg)Therapeutic ClassAdulticide & Insect Growth Regulator (IGR)Prescription StatusOTC Veterinary Parasiticide (No Rx required)

Safety Warnings, Precautions & Contraindications

• DO NOT USE ON DOGS / DO NOT USE DOG PIPETTES ON CATS: Use only the dedicated feline 0.5ml pipette. Dog spot-ons contain different drug concentrations and volumes, and some dog formulations contain permethrins that are fatal to cats.

• Age & Weight Restrictions: Do not use on kittens under 8 weeks of age or weighing less than 1 kg.

• Prevent Self-Grooming & Ingestion: Ingestion from licking wet solution can cause excessive hypersalivation and temporary lethargy due to the bitter alcohol base. Keep pets separated in multi-cat households until the application site dries completely.

• Sick or Debilitated Cats: Consult your veterinarian prior to application on sick, debilitated, pregnant, or lactating queens.

• Storage: Store below 30°C in a dry place protected from direct sunlight and heat. Keep sealed in original foil packaging until immediately prior to use. Keep strictly out of reach of children and domestic pets.