Zoetis Simparica Trio Monthly Tick, Flea, Heartworm & Deworming Chewable Tablet for Dogs

Active Ingredients & Mechanism of Action

• Sarolaner (Isoxazoline Class): Targets external parasites by overstimulating their central nervous system. Starts working on fleas within 4 hours and kills 6 tick species within 8 hours, breaking flea reproduction cycles and stopping tick-transmitted diseases.

• Moxidectin (Macrocyclic Lactone Class): Kills early-stage microfilariae of the mosquito-transmitted heartworm (Dirofilaria immitis), providing 100% prevention against fatal heartworm disease.

• Pyrantel Pamoate (Tetrahydropyrimidine Class): Clears common gastrointestinal parasites, specifically roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala).

Coverage & Parasite Spectrum

Parasite TypeTarget Pathogens / SpeciesAction & SpeedFleasAdult fleas (Ctenocephalides felis)Starts killing within 4 hours; prevents infestationsTicks (6 Species)Brown dog tick, American dog tick, Lone star tick, Black-legged tick, Gulf Coast tick, Asian longhorned tickStarts killing within 8 hoursHeartwormDirofilaria immitis100% prevention of mosquito-borne heartworm larvaeRoundwormsToxocara canis, Toxascaris leoninaClears adult and immature intestinal stagesHookwormsAncylostoma caninum, Uncinaria stenocephalaRemoves L4, immature adult, and adult hookwormsTapeworms (Indirect)Dipylidium caninumBreaks transmission cycle by killing vector fleas

Weight Bands & Dosing Guide

Administer one chewable tablet once every 30 days based on your dog's current body weight:

• 1.25 – 2.5 kg (Yellow): Toy Breeds & Puppies

• 2.5 – 5 kg (Purple): Small Breeds (Shih Tzu, Chihuahua, Pomeranian)

• 5 – 10 kg (Orange): Medium Breeds (Pug, French Bulldog, Small Beagle)

• 10 – 20 kg (Blue): Medium to Large Breeds (Beagle, Cocker Spaniel, Medium Indie)

• 20 – 40 kg (Green): Large Breeds (Labrador, Golden Retriever, Boxer, Indie)

• 40 – 60 kg (Brown): Giant Breeds (German Shepherd, Rottweiler, Great Dane)

Tip: Always weigh your dog prior to selection. If your dog falls between two weight bands, select the higher weight tier or consult your vet.

Administration Instructions

1. Offer the tablet directly as a treat or crush/mix it into a small portion of regular food.

2. Can be given with or without food (giving with a meal is suggested for dogs prone to nausea).

3. Ensure the complete tablet is swallowed. If vomiting occurs within 1 hour, re-administer a fresh tablet.

4. Administer once every 30 days without interruption for continuous year-round protection.

Safety Warnings & Precautions

• For canine use only. Do not administer to cats.

• Safe for puppies and dogs aged 8 weeks and older, weighing at least 1.25 kg.

• Neurological Precaution: Sarolaner is an isoxazoline. Use with caution in dogs with a history of seizures, tremors, or ataxia.

• Consult your veterinarian prior to use if your dog is pregnant, breeding, or lactating.