Bayer / Elanco Advocate (Imidacloprid 10% + Moxidectin 1.0%) All-in-One Broad-Spectrum Monthly Spot-On Solution for Large Cats (Over 4 kg, 0.8ml Pipette)

Active Pharmaceutical Profile & Clinical Mechanism

Active ConstituentConcentration / Pipette (0.8 ml)Pharmacological ClassMode of Action & Clinical RoleImidacloprid10% w/v (80 mg)Neonicotinoid EctoparasiticideActs as an agonist on postsynaptic nicotinic acetylcholine receptors in insects, causing continuous nerve firing, flaccid paralysis, and death on contact. Spreads across skin lipids without needing internal systemic ingestion by the flea.Moxidectin1.0% w/v (8 mg)Macrocyclic Lactone (Milbemycin class)Absorbs systemically through the skin; binds glutamate-gated chloride channels in nematodes and mites, causing hyperpolarization, paralysis, and death. Prevents heartworm development and clears gut worms and mites.Excipients (Benzyl Alcohol, BHT)q.s. to 0.8 mlTransdermal Spreading MatrixFacilitates fast transdermal absorption and smooth epidermal lipid migration.

Target Parasite Spectrum

• Fleas: Ctenocephalides felis (adults and larvae; reduces environmental flea burdens).

• Heartworms: Prevention of Dirofilaria immitis (L3 and L4 larvae).

• Gastrointestinal Roundworms: Toxocara cati (adults, immature adults, and L4 larvae).

• Gastrointestinal Hookworms: Ancylostoma tubaeforme (adults, immature adults, and L4 larvae).

• Lungworms: Aelurostrongylus abstrusus (adults).

• Mites: Ear mites (Otodectes cynotis) and Feline Mange (Notoedres cati).

Directions for Use & Step-by-Step Application

Apply topically as a single spot-on application once every 30 days as directed by your veterinarian.

1. Verify Weight: Confirm that your cat weighs more than 4 kg (for cats weighing 4 kg or less, use the Advocate for Small Cats 0.4ml pipette).

2. Open the Tube: Take one 0.8 ml tube from the blister pack. Hold the tube upright, pull off the cap, turn the cap around, and push the reverse end firmly onto the tip to puncture the protective safety seal.

3. Locate Application Site: Part the fur at the back of the cat's neck at the base of the skull until the skin is clearly visible. Placing it high on the neck ensures the cat cannot reach the site to groom or lick the wet liquid.

4. Apply Directly to Skin: Place the tip of the tube directly against the bare skin and squeeze the tube firmly twice to expel the complete 0.8 ml contents.

5. Post-Application Protocol:

   • Allow the site to dry naturally (do not massage, towel, or rub the area).

   • Keep multiple household cats separated for 2 to 3 hours to prevent mutual grooming at the wet site.

   • Do not apply onto broken, ulcerated, or wet skin.

   • Repeat once every month for continuous, year-round endectocide protection.

Bayer / Elanco Advocate Feline Weight-Band Guide

Packaging VariantPipette VolumeActive ImidaclopridActive MoxidectinTarget Cat Body WeightAdvocate for Small Cats (Orange)0.4 ml40 mg4 mgUp to 4 kg (Kittens & small cats)Advocate for Large Cats (Purple - This Product)0.8 ml80 mg8 mgOver 4 kg up to 8 kg (Large adult cats)

(For cats weighing greater than 8 kg, apply the appropriate combination of pipettes under veterinary guidance).

Product Specifications

ParameterDetailsBrandBayer Animal Health / Elanco India Pvt. Ltd.Product Trade NameAdvocate Spot-On Solution for Large CatsActive CompositionImidacloprid 10% w/v (80 mg) + Moxidectin 1.0% w/v (8 mg)Dosage FormTopical Spot-On Liquid SolutionPack ConfigurationSingle Dose 0.8 ml Pipette (Purple Box)Target SpeciesCats Only (Weight: >4 kg; Age: 9 weeks and older)Therapeutic ClassBroad-Spectrum Topical EndectocidePrescription StatusSchedule H Veterinary Prescription Medicine (Valid Rx required at PetMitra checkout)

Safety Warnings, Precautions & Storage

• Feline Use Only: Formulated specifically for feline physiology. Do NOT apply to dogs or other species.

• Age & Weight Limits: Do not use on kittens under 9 weeks of age or weighing less than 1 kg.

• Oral Ingestion Caution: If the cat licks the application site shortly after dosing, transient hypersalivation (drooling), agitation, or vomiting may occur due to the bitter taste of excipients. This usually resolves spontaneously without medical intervention.

• Avoid Contact with Eyes/Mouth: Prevent the liquid from entering the cat's eyes, ears, or mouth. Wash hands thoroughly with soap and water after application.

• Storage: Store below 30°C in a dry place. Keep protected from freezing, direct heat, and sunlight. Keep pipettes sealed in their protective foil blister until ready to apply. Keep strictly out of reach of children and household pets.