MSD Animal Health Bravecto 250mg (Fluralaner 250mg + Moxidectin 12.5mg) 12-Week Long-Acting Topical Spot-On Solution for Medium Cats (>2.8 to 6.25 kg, 1 Pipette)

Active Pharmaceutical Profile & Clinical Mechanism

Active ConstituentStrength per PipettePharmacological ClassTherapeutic Mechanism & Target SpectrumFluralaner250 mgSystemic Isoxazoline EctoparasiticidePotently antagonizes arthropod GABA-gated and glutamate-gated chloride channels, causing continuous hyper-excitation, paralysis, and rapid death of adult fleas, ticks, and mites. Sustains systemic therapeutic blood concentrations for 12 weeks.Moxidectin12.5 mgMacrocyclic Lactone (Milbemycin class)Stimulates release of inhibitory GABA in nematodes and mites, blocking neurotransmission to cause paralysis and clearance of microfilariae (heartworm prevention), adult/larval roundworms, hookworms, and ear mites.Excipientsq.s.Transdermal Spreading BaseFacilitates rapid transdermal uptake through the stratum corneum into systemic feline circulation without leaving sticky residues.

Clinical Indications

• Treatment and 12-week sustained prevention of flea infestations (Ctenocephalides felis).

• Treatment and control of tick infestations (Ixodes ricinus, Ixodes hexagonus, Dermacentor reticulatus, Rhipicephalus sanguineus).

• Treatment and eradication of ear mite infestations (Otodectes cynotis).

• Prevention of heartworm disease caused by Dirofilaria immitis for 12 weeks.

• Treatment of gastrointestinal nematode infections (adult and L4 larvae of Toxocara cati and Ancylostoma tubaeforme).

• Strategic adjunctive management of Flea Allergy Dermatitis (FAD) in cats.

Step-by-Step Directions for Use

Apply topically as a single spot application every 12 weeks as directed by your veterinarian.

1. Confirm Weight: Weigh your cat to ensure they fall within the >2.8 kg to 6.25 kg range.

2. Open the Pipette: Hold the pipette upright. Twist the cap clockwise or counterclockwise one full turn to break the internal seal (the cap remains on the pipette—do not pull it off).

3. Locate Application Site: Ensure your cat is standing or lying comfortably. Part the fur at the base of the skull (or along the dorsal midline of the neck) until the bare skin is clearly visible. This location prevents the cat from turning around and licking the wet solution.

4. Apply Directly to Skin: Place the tip of the pipette directly onto the exposed skin and squeeze the tube firmly 2 to 3 times to empty the entire contents in one spot.

5. Post-Application Care:

   • Keep the treated cat separated from other pets for 2 to 3 hours until the spot is dry to prevent reciprocal grooming.

   • Do not apply onto broken, inflamed, or wet skin.

   • Repeat every 12 weeks for continuous year-round feline protection.

Bravecto Feline Weight-Based Variant Guide

Packaging VariantFluralaner ContentMoxidectin ContentCat Body Weight BandRepresentative BreedsSmall Cats / Kittens112.5 mg5.6 mg1.2 kg to 2.8 kgKittens (over 11 weeks), Singapura, Munchkin, juvenile catsMedium Cats (This Product)250 mg12.5 mg>2.8 kg to 6.25 kgDomestic Shorthair, Persian, Siamese, British Shorthair, Indie CatsLarge Cats500 mg25 mg>6.25 kg to 12.5 kgMaine Coon, Ragdoll, Norwegian Forest Cat, large Toms

Product Specifications

ParameterDetailsBrandMSD Animal Health (Intervet India Pvt. Ltd. / Merck)Product Trade NameBravecto Spot-On Solution for Medium CatsActive CompositionFluralaner 250 mg + Moxidectin 12.5 mgDosage FormTopical Spot-On Liquid SolutionPack Size1 Single-Dose Pipette (TWIST´N´USE)Duration of ActionUp to 12 Weeks (3 Full Months) per pipetteTarget SpeciesCats Only (Weight: >2.8 kg to 6.25 kg; Age: 11 weeks and older)Therapeutic ClassBroad-Spectrum Endectocide (Isoxazoline + Macrocyclic Lactone)Prescription StatusSchedule H Veterinary Prescription Medicine (Valid Rx required at PetMitra checkout)

Safety Warnings, Precautions & Storage

• Feline Specific: For external topical veterinary use on cats only. Do NOT administer orally or apply to dogs.

• Age & Weight Restrictions: Do not use on kittens under 11 weeks of age or weighing less than 1.2 kg. For cats weighing over 6.25 kg, select the 500 mg variant.

• Grooming & Ingestion Caution: If the cat accidentally licks the application site shortly after application, transient excessive salivation (drooling), vomiting, or mild tremors may occur due to the bitter taste and excipients. This typically resolves spontaneously.

• Neurological History: Use with caution in cats with a history of epilepsy, neurological conditions, or seizures.

• Storage: Store below 30°C. Protect from freezing and direct sunlight. Keep the pipette sealed inside the original blister foil pouch until immediately before application. Keep strictly out of reach of children and other pets.