MSD Animal Health Bravecto 500mg (Fluralaner 500mg + Moxidectin 25mg) 12-Week Long-Acting Topical Spot-On Solution for Large Cats (>6.25 to 12.5 kg, 1 Pipette / Tube)

Active Pharmaceutical Profile & Clinical Mechanism

Active ConstituentStrength per Pipette (1.79 ml)Pharmacological ClassTherapeutic Mechanism & Target SpectrumFluralaner500 mgSystemic Isoxazoline EctoparasiticidePotently antagonizes arthropod GABA-gated and glutamate-gated chloride channels, causing continuous hyper-excitation, paralysis, and rapid death of adult fleas, ticks, and mites. Sustains systemic therapeutic blood concentrations for 12 weeks.Moxidectin25 mgMacrocyclic Lactone (Milbemycin class)Stimulates release of inhibitory GABA in nematodes and mites, blocking neurotransmission to cause paralysis and clearance of microfilariae (heartworm prevention), adult/larval roundworms, hookworms, and ear mites.Excipientsq.s. (includes BHT 1.07 mg/ml)Transdermal Spreading BaseFacilitates rapid transdermal uptake through the stratum corneum into systemic feline circulation without leaving sticky residues.

Clinical Indications

• Treatment and 12-week sustained prevention of flea infestations (Ctenocephalides felis).

• Treatment and control of tick infestations (Ixodes ricinus, Ixodes hexagonus, Dermacentor reticulatus, Rhipicephalus sanguineus).

• Treatment and eradication of ear mite infestations (Otodectes cynotis).

• Prevention of heartworm disease caused by Dirofilaria immitis for 12 weeks.

• Treatment of gastrointestinal nematode infections (adult and 4th stage larvae of Toxocara cati and Ancylostoma tubaeforme).

• Strategic adjunctive management of Flea Allergy Dermatitis (FAD) in large cats.

Step-by-Step Directions for Use

Apply topically as a single spot application every 12 weeks as directed by your veterinarian.

1. Confirm Weight: Weigh your cat to ensure they fall within the >6.25 kg to 12.5 kg weight band.

2. Open the Pipette: Hold the pipette upright. Twist the cap clockwise or counterclockwise one full turn to break the internal seal (the cap remains on the pipette—do not pull it off).

3. Locate Application Site: Ensure your cat is standing or lying horizontally. Part the fur at the base of the skull (or along the dorsal midline of the neck) until the bare skin is clearly visible. This location prevents the cat from turning around and licking the wet solution.

4. Apply Directly to Skin: Place the tip of the pipette directly onto the exposed skin and squeeze the tube firmly 2 to 3 times to empty the contents. For large cats with higher volume (1.79 ml), applying in one or two spots along the midline of the neck helps avoid liquid runoff.

5. Post-Application Care:

   • Keep the treated cat separated from other pets for 2 to 3 hours until the spot is dry to prevent reciprocal grooming.

   • Do not apply onto broken, inflamed, or wet skin.

   • Repeat every 12 weeks for continuous year-round feline protection.

Bravecto Feline Weight-Based Variant Guide

Packaging VariantFluralaner ContentMoxidectin ContentCat Body Weight BandRepresentative BreedsSmall Cats / Kittens112.5 mg5.6 mg1.2 kg to 2.8 kgKittens (over 11 weeks), Singapura, Munchkin, juvenile catsMedium Cats250 mg12.5 mg>2.8 kg to 6.25 kgDomestic Shorthair, Persian, Siamese, British Shorthair, Indie CatsLarge Cats (This Product)500 mg25 mg>6.25 kg to 12.5 kgMaine Coon, Ragdoll, Norwegian Forest Cat, large adult Toms

(For cats weighing over 12.5 kg, use an appropriate combination of two pipettes as directed by your veterinarian).

Product Specifications

ParameterDetailsBrandMSD Animal Health (Intervet India Pvt. Ltd. / Merck)Product Trade NameBravecto Spot-On Solution for Large CatsActive CompositionFluralaner 500 mg + Moxidectin 25 mg (per 1.79 ml pipette)Dosage FormTopical Spot-On Liquid SolutionPack Size1 Single-Dose Pipette / Tube (TWIST´N´USE)Duration of ActionUp to 12 Weeks (3 Full Months) per pipetteTarget SpeciesCats Only (Weight: >6.25 kg to 12.5 kg; Age: 11 weeks and older)Therapeutic ClassBroad-Spectrum Endectocide (Isoxazoline + Macrocyclic Lactone)Prescription StatusSchedule H Veterinary Prescription Medicine (Valid Rx required at PetMitra checkout)

Safety Warnings, Precautions & Storage

• Feline Specific: For external topical veterinary use on cats only. Do NOT administer orally or apply to dogs.

• Weight Accuracy: Ensure your cat weighs more than 6.25 kg. For cats weighing 6.25 kg or less, select the 250 mg or 112.5 mg variant.

• Grooming & Ingestion Caution: If the cat accidentally licks the application site shortly after application, transient excessive salivation (drooling), vomiting, or mild tremors may occur due to the bitter taste of the vehicle. This typically resolves spontaneously.

• Neurological History: Use with caution in cats with a history of epilepsy, neurological conditions, or seizures.

• Storage: Store below 30°C. Protect from freezing and direct sunlight. Keep the pipette sealed inside the original blister foil pouch until immediately before application. Keep strictly out of reach of children and other pets.