Savavet Felintra (Itraconazole 10 mg/ml) Oral Solution for Cats & Kittens

Active Formulation Matrix & Pharmacological Profile

Pharmacological ParameterSpecificationMode of Action & Clinical RelevanceActive MoleculeItraconazole (10 mg / ml)Synthetic triazole antifungal agent.Molecular Mechanism14-$\alpha$-Demethylase InhibitionDepletes fungal membrane ergosterol, disrupting cell membrane permeability and viability.Tissue DistributionKeratophilic & SebotropicConcentrates heavily in the stratum corneum, sebum, hair bulbs, and nails (tissue levels > plasma levels).Oral BioavailabilityHigh in Fed StateBioavailability is maximized when administered with or directly after a meal.Plasma Half-Life ($t_{1/2}$)Approx. 24 to 36 Hours in CatsSupports once-daily administration or pulse-dosing protocols.Metabolism & EliminationHepatic biotransformation; biliary excretionExtensively metabolized by the liver; excreted via bile and feces.

Antifungal Spectrum & Targeted Pathogens

Fungal CategorySpecific PathogensClinical Disease / Lesions in CatsDermatophytes (Ringworm)Microsporum canis, Trichophyton mentagrophytes, Microsporum gypseumFocal/multifocal alopecia, broken hairs, circular scaling, miliary dermatitis, pseudomycetomas, and zoonotic contagion.Yeast OrganismsMalassezia pachydermatis, Candida albicansErythematous, greasy, malodorous otitis externa, facial fold intertrigo, and generalized paronychia.Deep / Systemic MycosesCryptococcus neoformans, Histoplasma capsulatum, BlastomycesNasal swelling, cutaneous ulcerated nodules, systemic lymphadenopathy, and pulmonary granulomas.

Comparison: Savavet Felintra vs. Terbinafine vs. Generic Human Itraconazole Capsules

Clinical FeatureSavavet Felintra Oral Solution (Current)Terbinafine (Lamisil)Generic Human Itraconazole 100mg CapsulesFormulation TypeStandardized 10 mg/ml Oral LiquidOral TabletsDry Beaded Micro-Pellet CapsulesFeline Dosing PrecisionExact (via calibrated 0.1 ml increments)Difficult to divide for low body weightsVery poor (pellets cannot be divided evenly)Feline GI BioavailabilityOptimized liquid absorptionVariableUnpredictable if beads are crushed or chewedGold Standard for RingwormYes (First-line choice globally)Second-line alternativeVariable clinical responseResidual Follicular EffectHigh (Persists 2–4 weeks post-treatment)ModerateHigh (if absorbed)Ease of AdministrationEasy liquid syringe deliveryCrushed bitter tablets often rejectedChallenging to pill in cats

Dosage, Dosing Protocols & Directions for Use

Strictly for oral administration in cats and kittens under direct veterinary supervision:

Standard Clinical Veterinary Dosing Regimens:

• Standard Daily Dosage: 5 mg per kg body weight (0.5 ml per kg body weight) administered orally once daily (every 24 hours).

• The Pulse Dosing Protocol (Widely Preferred by Feline Dermatologists):

  • Week 1: Administer 5 mg/kg once daily for 7 consecutive days.

  • Week 2: Rest week (No medication). (Residual tissue concentrations remain therapeutic).

  • Week 3: Administer 5 mg/kg once daily for 7 consecutive days.

  • Week 4: Rest week (No medication).

  • Week 5: Administer 5 mg/kg once daily for 7 consecutive days.

  • Note: Repeat until two consecutive fungal cultures (DTM) or PCR tests return negative.

Weight-Based Daily Dosing Chart (at 5 mg / 0.5 ml per kg):

Cat Body WeightDaily Volume of Felintra (10 mg/ml)Administration Strategy1.0 kg (Kitten)0.5 mlMeasure using the fine-gauge oral syringe2.0 kg1.0 mlAdminister with or after feeding3.0 kg1.5 mlAdminister slowly into the side of the mouth4.0 kg (Standard Adult)2.0 mlCan be mixed into a small amount of wet food5.0 kg2.5 mlGive at the same time each day6.0 kg and Above3.0 mlLarge breeds (Maine Coons, mature toms)

Step-by-Step Administration Steps:

1. Feed First: Administer during or immediately after a meal containing dietary fat (e.g., wet food like Purina Felix). Food intake lowers gastric pH and stimulates bile flow, maximizing itraconazole absorption.

2. Draw Exact Volume: Insert the syringe into the bottle adapter and draw the prescribed volume based on weight.

3. Gentle Administration: Place the syringe tip into the corner of the cat’s mouth behind the canine teeth. Slowly depress the plunger to allow the cat to swallow naturally; avoid shooting the liquid down the throat to prevent aspiration.

4. Complete the Prescribed Course: Never stop therapy prematurely when skin lesions visually resolve. Fungal spores linger on hairs; stopping early leads to immediate relapse.

Product Specifications

ParameterDetailsBrandSavavet (Sava Healthcare Limited)Product Trade NameFelintra Oral Solution for CatsActive Pharmaceutical IngredientItraconazole 10 mg per mlPharmacological ClassTriazole Antifungal AgentTarget SpeciesCats and KittensDosage FormLiquid Oral SolutionPackaging Size60 ml Amber Bottle with Calibrated Dosing SyringePrescription StatusPrescription Veterinary Medicine (Rx Required)

Safety Warnings, Precautions & Contraindications

• Liver Function Monitoring: Itraconazole is metabolized by the liver. In cats undergoing courses longer than 4 weeks, periodic monitoring of serum liver enzymes (ALT, AST, ALP, Total Bilirubin) is advised.

• Pre-Existing Hepatic Disease: Contraindicated in cats with severe pre-existing liver impairment or jaundice.

• Pregnancy & Lactation: Do not administer to pregnant queens (potential teratogenic effects) or nursing mothers.

• Signs of Intolerance: Discontinue temporarily and consult your veterinarian if the cat exhibits persistent anorexia, vomiting, diarrhea, or yellowing of the sclera/ears (icterus).

• Storage Instructions: Store at room temperature (below 25°C) in a dry place away from direct sunlight. Do not refrigerate or freeze. Keep the bottle tightly capped and out of reach of children and other animals.