Intas Griptol-N Broad-Spectrum Antibacterial, Antiprotozoal & Antidiarrhoeal Oral Suspension for Dogs

Active Pharmaceutical Matrix & Pharmacological Actions

Active ConstituentPharmacological ClassTherapeutic Target & Biological Mode of ActionLevofloxacin Hemihydrate IP3rd-Generation Fluoroquinolone AntibacterialInhibits bacterial DNA gyrase & topoisomerase IV; arrests DNA replication; bactericidal against aerobic Gram(-) and Gram(+) pathogens (E. coli, Salmonella, Proteus, Campylobacter).Ornidazole IP5-Nitroimidazole Antiprotozoal & AntianaerobicReduced intracellularly to form free radical intermediates that cleave microbial helical DNA; bactericidal/protozoacidal against Anaerobes (Clostridium) and Protozoa (Giardia, Coccidia, Trichomonas).Flavored Suspension VehiclePalatable Base q.s. to 5 mlBuffers active ingredients to minimize gastric nausea and support stress-free oral acceptance.

Clinical Veterinary Indications

• Mixed bacterial and protozoal infectious gastroenteritis in dogs and puppies.

• Canine Giardiasis (Giardia lamblia / duodenalis) causing foul-smelling, fatty, chronic recurrent diarrhea.

• Intestinal Coccidiosis and Trichomoniasis in puppies.

• Acute or chronic enteritis caused by Clostridium perfringens, Escherichia coli, or Salmonella spp.

• Canine infectious dysentery characterized by blood, mucus, and painful tenesmus.

• Bacterial enteritis secondary to viral insult (post-parvovirus mucosal recovery phase under veterinary supervision).

Comparison: Intas Griptol-N vs. Metronidazole Suspension vs. Standard Antidiarrheals

Clinical ParameterIntas Griptol-N Suspension (Current)Metronidazole Oral SuspensionPectin / Kaolin Absorbent SuspensionsActive CompositionLevofloxacin + OrnidazoleMetronidazole aloneKaolin + Pectin / BismuthPathogen CoverageAerobic Gram(+/-) + Anaerobic + ProtozoaAnaerobic bacteria + Protozoa onlyNone (Absorbs toxins/fluids only)Antiprotozoal PotencyHigh (Giardia & Coccidia)Moderate to High (Giardia)NoneNeurological SafetyHigh (Minimal risk of ataxia/tremors)Narrow margin (Risk of neurotoxicity)HighDosing FrequencyEvery 12 to 24 hours (Long half-life)Every 8 to 12 hoursEvery 6 to 8 hoursPrimary IndicationComplicated, mixed, or severe infectious diarrheaStandard anaerobic enteritisMild dietary indiscretion / toxins

Dosage & Administration Guidelines

Administer orally strictly under direct veterinary prescription based on body weight:

• Standard Clinical Dosing Parameters (General Reference):

  • Typically dosed based on Levofloxacin (7.5 mg to 10 mg/kg b.wt) and Ornidazole (15 mg to 20 mg/kg b.wt), administered once to twice daily (every 12 to 24 hours) depending on infection severity.

  • Standard treatment duration: Administer consistently for 3 to 5 consecutive days (or up to 7 days for chronic Giardiasis).

• Practical Weight-to-Volume Reference Guide (Twice-Daily Administration):

Pet Body Weight RangeTypical Liquid Dose (Twice Daily)Clinical Context2.5 kg to 5.0 kg1.25 ml to 2.5 mlToy puppies, small breeds (Shih Tzu, Pug pups)5.0 kg to 10.0 kg2.5 ml to 5.0 mlSmall dogs (Pomeranians, Lhasa Apsos, Beagles)10.0 kg to 20.0 kg5.0 ml to 10.0 mlMedium dogs (Indies, Cocker Spaniels, French Bulldogs)Above 20.0 kgConsult vet for milliliter titration (or transition to tablets)Large breeds (Labradors, GSDs)

• Administration Instructions:

  • Shake the bottle thoroughly before measuring each dose.

  • Can be administered directly into the cheek pouch using the included oral spoon or syringe, or mixed into a small portion of bland food (boiled chicken broth or curd-rice).

  • COURSE COMPLETION (CRITICAL): Complete the entire 3- to 5-day course as prescribed. Stopping medication prematurely after the first firm stool can lead to protozoal relapse and resistant bacterial strains.

Product Specifications

ParameterDetailsBrandIntas Pharmaceuticals Ltd. (Intas Animal Health - PET Division)Product Trade NameGriptol-N Antidiarrhoeal SuspensionProduct ClassificationBroad-Spectrum Veterinary Antibacterial & Antiprotozoal Gastrointestinal FormulationActive CompositionLevofloxacin Hemihydrate IP + Ornidazole IPDosage FormFlavored Oral Liquid SuspensionPackaging Size60 ml Dispensing Bottle with Calibrated Feeding SpoonTarget SpeciesDogs and PuppiesTherapeutic ClassGastrointestinal Fluoroquinolone & Nitroimidazole AntimicrobialPrescription StatusSchedule H / Veterinary Prescription Medicine (Rx required)

Safety Warnings, Precautions & Contraindications

• Prescription Only (Rx): Schedule H antimicrobial. Must be administered under licensed veterinary diagnosis and supervision.

• Age & Cartilage Development Precaution: Fluoroquinolones (such as Levofloxacin) carry a potential risk of articular cartilage erosion in rapidly growing pediatric pups. Use in young puppies under 4 months of age should be reserved for confirmed susceptible infections where alternative therapies are unsuitable, under strict veterinary monitoring.

• Not for Cats Without Explicit Guidance: Formulated and dosed specifically for canine physiology.

• Separation from Gut Protectants & Multivalent Ions: Do not administer concurrently with oral antacids, sucralfate, or high-mineral supplements (Intacal Pet Max or Feritas). Cations ($Ca^{2+}$, $Fe^{2+}$, $Mg^{2+}$, $Al^{3+}$) chelate fluoroquinolones, significantly blocking absorption. Administer Griptol-N at least 2 hours before or after mineral syrups or charcoal tablets.

• Rehydration Therapy is Essential: Antimicrobials eradicate pathogens, but they do not replace lost fluids. For dogs with active diarrhea, concurrently administer isotonic oral rehydration solutions (Intas Ordelyte) to maintain fluid and electrolyte balance.

• Storage: Store below 25°C in a cool, dry place protected from heat and direct sunlight. Keep the bottle tightly capped and out of reach of children and domestic pets.