Savavet Carodyl (Carprofen 75 mg) Chewable Analgesic & Anti-Inflammatory Tablets for Medium & Large Dogs

Active Formulation Matrix & Pharmacological Profile

ParameterSpecificationClinical & Pharmacological MechanismActive Pharmaceutical IngredientCarprofen (75 mg per tablet)Non-narcotic, propionic acid derivative NSAID.Enzymatic TargetPreferential COX-2 Inhibition (vs. COX-1)Suppresses inflammatory prostaglandin synthesis ($PGE_2$) while sparing constitutional COX-1 mucosal defenses.Therapeutic ActionsAnalgesic, Anti-Inflammatory, AntipyreticReduces joint effusion, dampens pain signaling pathways, and helps lower fever.Oral Absorption ($T_{max}$)1 to 3 HoursRapid systemic uptake; bioavailability exceeds 90% in dogs.Plasma Half-Life ($t_{1/2}$)Approx. 8 to 10 HoursSupports convenient once-daily or divided twice-daily dosing schedules.Metabolism & EliminationHepatic biotransformation; biliary & fecal excretionGlucuronidated and oxidized in the liver; primarily eliminated via bile into feces.

Clinical Veterinary Indications

• Relief of pain and inflammation associated with canine osteoarthritis and degenerative joint disease (DJD).

• Control of post-operative pain following orthopedic surgeries (e.g., TPLO, cruciate ligament repair, femoral head ostectomy, fracture management).

• Management of post-surgical discomfort associated with soft-tissue procedures (e.g., ovariohysterectomy, castration, mass removals).

• Musculoskeletal pain management for acute soft-tissue trauma, ligament sprains, muscle strains, and tendonitis.

Comparison: Savavet Carodyl (Carprofen) vs. Savavet Metaflam (Meloxicam)

ParameterSavavet Carodyl 75 mg (Current)Savavet Metaflam 2.5 mgActive MoleculeCarprofen (75 mg)Meloxicam (2.5 mg)Chemical ClassPropionic Acid DerivativeOxicam DerivativeDosing Administration4.0 mg/kg once daily OR 2.0 mg/kg twice daily0.2 mg/kg loading Day 1; 0.1 mg/kg daily maintenanceTarget Weight BracketMedium to Large Dogs (approx. 18 kg to 37.5 kg per tablet)Small to Medium Dogs (1 tablet per 25 kg maintenance)Loading Dose RequirementNo loading dose required (uniform therapeutic dosing)Initial 2x loading dose required on Day 1Clinical StrengthFavored in intensive orthopedic surgery recoveryBroad use for chronic OA and systemic fever reduction

Dosage & Administration Protocol

Strictly for oral administration in dogs under veterinary supervision:

Standard Clinical Dosage:

• General Dose Rate: Administer 4.0 mg Carprofen per kg body weight once daily, OR divide into 2.0 mg per kg body weight twice daily (every 12 hours).

  • Osteoarthritis Management: 4.0 mg/kg once daily (or 2.0 mg/kg twice daily) for the recommended clinical duration. For chronic therapy, the veterinarian may adjust down to the lowest effective maintenance dose once clinical improvement is stabilized.

  • Surgical Pain: Administer approximately 2 hours prior to the procedure or immediately post-operatively, continuing for 3 to 5 days as directed.

Weight-Based Daily Dosing Reference (at 4.0 mg/kg/day):

Dog Body Weight BracketDaily Dose (Total Carprofen)Carodyl 75 mg Dosing Strategy9.0 kg to 10.0 kg37.5 mg½ Tablet once daily (using scored breakline)18.0 kg to 19.0 kg75.0 mg1 Tablet once daily (or ½ tablet twice daily)27.0 kg to 28.0 kg112.5 mg1½ Tablets once daily36.0 kg to 38.0 kg150.0 mg2 Tablets once daily (or 1 tablet twice daily)54.0 kg to 56.0 kg (Giant)225.0 mg3 Tablets once daily

Administration Tips & Gastric Protection:

• Administer With or After Food: Always give Carodyl with a meal or directly after feeding to buffer the stomach lining and reduce the chance of digestive upset.

• Gastroprotective Co-Therapy: In dogs with sensitive stomachs or during long-term therapy, veterinarians frequently recommend co-administering an antacid or proton pump inhibitor (such as Pantoprazole or Omeprazole) 30 minutes before food.

• Maintain Clean Water Access: Ensure your dog has unrestricted access to fresh drinking water to maintain proper renal hydration throughout treatment.

Savavet Carodyl Strength Lineup

Strength VariantCarprofen per TabletTarget Dog SizeCarodyl 20 mg20 mgSmall & Toy Breeds (approx. 5 kg)Carodyl 75 mg [Current]75 mgMedium & Large Breeds (approx. 18 kg to 38 kg)Carodyl 100 mg100 mgLarge & Giant Breeds (approx. 25 kg to 50 kg)

Product Specifications

ParameterDetailsBrandSavavet (Sava Healthcare Limited)Product Trade NameCarodyl 75 Chewable TabletsActive MoleculeCarprofen 75 mg per tabletTherapeutic ClassNon-Steroidal Anti-Inflammatory Drug (NSAID)Chemical FamilyPropionic Acid DerivativeDosage FormFlavored, Scored Oral Chewable TabletPackaging PresentationBlister Strip of 6 Chewable TabletsTarget SpeciesDogs OnlyPrescription StatusPrescription Veterinary Medicine (Rx Required)

Contraindications, Safety Warnings & Precautions

• STRICT FELINE CONTRAINDICATION: Do NOT administer Carodyl (Carprofen) to cats. Cats have a limited capacity to metabolize propionic acid NSAIDs due to deficient hepatic glucuronidation pathways. Administration in felines can cause rapid gastrointestinal ulceration, severe toxicity, and acute kidney injury.

• Concurrent NSAID / Corticosteroid Prohibition: Never co-administer Carodyl with other NSAIDs (e.g., Meloxicam, Firocoxib) or systemic corticosteroids (e.g., Prednisolone, Dexamethasone). Combining these agents significantly increases the risk of severe gastrointestinal perforations, bleeding ulcers, and renal impairment. A washout period of 3 to 7 days is required when switching medications.

• Pre-Existing Organ Dysfunction: Contraindicated in dogs with active gastrointestinal ulceration, severe hepatic disease, bleeding disorders, or renal insufficiency. Dehydrated or hypovolemic dogs should not receive Carprofen until stabilized.

• Clinical Monitoring: Discontinue administration immediately and consult your veterinarian if the dog shows signs of adverse reactions, such as persistent vomiting, dark/tarry stools (melena), loss of appetite, lethargy, or yellowing of the gums/eyes (jaundice).

• Storage Instructions: Store at room temperature (below 30°C) in a dry place away from heat and direct sunlight. Keep tablets sealed in their original blister pack until dispensing. Keep strictly out of reach of children and domestic pets.