SavaVet Ichmune C 25mg (Cyclosporine) Immunomodulator Capsules/Tablets for Dogs (Strip of 6)

Active Pharmaceutical Profile & Clinical Action

Active ConstituentStrength per UnitPharmacological ClassTherapeutic MechanismCyclosporine USP (Modified / Microemulsion)25 mgCalcineurin Inhibitor / ImmunosuppressantForms a complex with intracellular cyclophilin to inhibit calcineurin phosphatase. This prevents nuclear translocation of NF-AT, halting Interleukin-2 (IL-2) synthesis and inhibiting T-cell-driven allergic and autoimmune responses.

Clinical Indications

IndicationPathological PresentationTherapeutic Benefit of Ichmune CCanine Atopic DermatitisChronic environmental allergies, pododermatitis, red belly, flank scratchingSuppresses allergic cascade; reduces pruritus and cutaneous erythemaPerianal Fistulas (Anal Furunculosis)Ulcerated, draining sinuses, pain during defecation, foul odorHeals deep fistulous tracts without invasive surgical resectionAutoimmune Skin ConditionsPemphigus foliaceus, discoid lupus erythematosus (DLE)Dampens auto-reactive immune responses against skin structural proteinsSteroid-Intolerant AtopyDogs exhibiting adverse reactions to long-term glucocorticoidsSafe transition therapy to taper off systemic steroids

Dosage & Administration Guidelines

Administer strictly according to your veterinarian’s written prescription and weight calculations.

• Target Therapeutic Dose: The standard clinical dosage for canine atopic dermatitis is 5 mg/kg body weight once daily.

  • Dogs weighing ~5 kg: One 25 mg capsule once daily.

  • Dogs weighing ~10 kg: Two 25 mg capsules once daily (or one 50 mg capsule).

• Administration Timing:

  • For optimal bioavailability, administer on an empty stomach (either 1 hour before a meal or 2 hours after feeding).

  • Tip for Sensitive Stomachs: If your dog experiences mild nausea or vomiting, temporarily giving the medication with a small spoonful of food or chilling the capsules in the refrigerator before administration can help mitigate digestive sensitivity.

• Treatment Protocol & Tapering:

  • Initial Phase: Administer daily for 4 to 6 weeks until significant clinical improvement is achieved.

  • Maintenance Phase: Once pruritus and lesions are controlled, your vet may taper administration to every other day, and eventually to twice weekly for ongoing maintenance.

• Do Not Crush or Open: Capsules/tablets should be swallowed whole; do not puncture or dissolve.

Product Specifications

ParameterDetailsBrandSavaVet (Sava Healthcare Ltd.)Product Trade NameIchmune C 25Active CompositionCyclosporine USP 25 mgDosage FormSoft Gelatin Capsules / Oral TabletsNet QuantityStrip of 6 UnitsTarget SpeciesDogs OnlyTherapeutic ClassImmunomodulator / Calcineurin InhibitorPrescription StatusSchedule H Prescription Medicine (Upload Rx at PetMitra checkout)

Safety Warnings, Precautions & Storage

• Prescription Mandatory: This is a potent immunomodulating drug. Use only under close veterinary supervision.

• Infections & Parasites: Ensure active bacterial pyoderma, fungal/yeast infections, and flea infestations are treated prior to initiating or alongside immunosuppressive therapy.

• Vaccination Guidance: Avoid administering modified live vaccines immediately before, during, or right after high-dose cyclosporine therapy.

• Contraindications: Do not use in dogs with a history of malignant neoplasia or known hypersensitivity to cyclosporine. Not recommended for dogs under 6 months of age or weighing less than 2 kg.

• Common Side Effects: Mild, transient gastrointestinal signs (vomiting, soft stools) are common during the first week and usually subside spontaneously. Gingival hyperplasia (gum enlargement) or hypertrichosis (excessive hair growth) may rarely occur with prolonged therapy.

• Storage: Store below 25°C in a dry place. Protect from heat, direct sunlight, and excessive moisture. Keep blister strip sealed until dose time. Keep out of reach of children and household pets.