Virbac Pronefra Advanced Renoprotective Oral Suspension for Dogs & Cats(180ml + 180ml = 360ml Total)

Active Formulation Matrix & Pharmacological Actions

Active ComponentFunctional ClassificationTargeted Mechanism in Chronic Kidney Disease (CKD)Calcium Carbonate & Magnesium CarbonateIntestinal / Enteric Phosphate BindersChemically bind dietary phosphorus within the digestive tract lumen; block phosphate absorption to protect remaining functional nephrons.ChitosanNatural Marine Biopolymer (Uremic Toxin Trap)Adsorbs indoxyl sulfate, urea precursors, and nitrogenous toxins in the gut, reducing circulating uremic waste and associated nausea.Astragalus Extract (Astragalus membranaceus)Renoprotective Botanical PolysaccharideAntioxidant and anti-fibrotic actions; helps preserve renal microvascular architecture and support glomerular filtration.Marine Oligopeptides (Hydrolyzed Fish Protein)Bioactive PeptidesSupport vascular tone and arterial elasticity, promoting healthy blood flow to delicate nephrons.Palatable Lipid VehiclePoultry & Liver Derivatives, Sunflower OilHigh-energy, palatable carrier base designed for voluntary intake by renal-compromised pets.

Clinical Veterinary Indications

• Nutritional management of Chronic Kidney Disease (CKD / Renal Failure) across IRIS Stages 1 through 4 in cats and dogs.

• Hyperphosphatemia management alongside commercial or home-cooked renal diets.

• Uremic syndrome, metabolic nausea, and inappetence associated with elevated blood urea nitrogen (BUN) and creatinine levels.

• Proteinuria and progressive renal fibrosis support under veterinary direction.

• Adjunct nutritional therapy alongside ACE inhibitors, ARBs, and subcutaneous fluid therapy.

Comparison: Virbac Pronefra vs. Standard Single-Agent Binders

Feature / MetricVirbac Pronefra Oral SuspensionSingle Phosphate Binders (e.g., Pure Calcium Carbonate)Therapeutic Scope4-in-1 Multimodal Protection (Phosphate + Uremic Toxins + Fibrosis + Vascular Support)Single action (Phosphate binding only)Toxin ReductionYes (Chitosan traps nitrogenous uremic toxins)No effect on circulating uremic wasteTissue ArchitectureYes (Astragalus helps slow fibrotic remodeling)No direct structural supportAdministration FormatFlavored liquid suspension with body-weight syringeChalky, bitter powders often rejected by finicky catsSpecies OptimizationClinically calibrated for both cats and dogsOften human-grade powders requiring difficult re-dosing

Dosage & Administration Guidelines

Shake bottle vigorously before each administration. Use the provided calibrated body-weight syringe:

• Standard Dosing Rates:

  • Cats: 1 ml per 4 kg body weight, administered twice daily (with or close to meals).

  • Dogs: 1 ml per 5 kg body weight, administered twice daily (with or close to meals).

• Dosing Reference Table:

Pet Type & Body WeightMorning Dose (with Meal)Evening Dose (with Meal)Total Daily VolumeCat (2 kg)0.5 ml0.5 ml1.0 ml dailyCat (4 kg)1.0 ml1.0 ml2.0 ml dailySmall Dog (5 kg)1.0 ml1.0 ml2.0 ml dailyMedium Dog (10 kg)2.0 ml2.0 ml4.0 ml dailyLarge Dog (20 kg)4.0 ml4.0 ml8.0 ml daily

• Administration Instructions:

  1. Shake the bottle thoroughly to ensure uniform suspension of active mineral binders.

  2. Unscrew the cap and insert the dosing syringe into the plastic neck adapter.

  3. Turn the bottle upside down and draw the exact dose based on your pet's weight.

  4. Dispense over your pet's regular renal diet, mix into a small treat, or administer directly into the side of the mouth.

  5. Wash the syringe with clean warm water after each use and allow to dry.

Product Specifications

ParameterDetailsBrandVirbac Animal Health (Virbac S.A., France / Virbac India)Product Trade NamePronefra Renoprotective Oral Suspension (Twin Pack)Product ClassificationVeterinary Complementary Renal Feed SupplementKey Active MatrixCalcium Carbonate, Magnesium Carbonate, Chitosan, Astragalus, Marine OligopeptidesDosage FormPalatable Viscous Oral Liquid SuspensionCombo Pack Contents2 x 180 ml Bottles (360 ml Total) with 2 Calibrated Dosing SyringesTarget SpeciesCats and Dogs across all life stagesTherapeutic ClassRenal Protectant & Enteric Phosphate BinderPrescription StatusVeterinary Complementary Formulation (Use under veterinary guidance)

Safety Warnings, Precautions & Storage

• Meal Timing is Critical: Administer with or immediately around feeding times. Phosphate binders must interact directly with ingested food in the stomach and upper intestine to bind dietary phosphorus effectively.

• Routine Renal Monitoring: Pets on long-term phosphate binders should have serum phosphorus, calcium, BUN, and creatinine levels checked by a veterinarian every 3 to 6 months to calibrate management.

• Separation from Oral Medications: Administer Pronefra at least 1 to 2 hours apart from other oral prescription medications (such as ACE inhibitors, antibiotics, or heart medications), as mineral binders can reduce the absorption of concurrent drugs.

• Hydration: Always ensure clean, fresh drinking water is accessible to support renal flushing.

• Storage: Store below 25°C in a dry place protected from direct sunlight. Do not refrigerate or freeze. Keep bottles tightly sealed. Keep strictly out of reach of children and domestic