Vivaldis Atosporin 50mg (Cyclosporine) Immunosuppressive Capsules for Dogs (Strip of 5 Capsules)

Active Composition & Pharmacodynamics

• Active Ingredient: Cyclosporine IP (Modified) 50 mg per soft gelatin capsule.

• Therapeutic Class: Calcineurin Inhibitor / Immunosuppressant / Immunomodulator.

• Mechanism of Action: Cyclosporine binds intracellularly to cyclophilin, forming a complex that inhibits the enzyme calcineurin. This inhibition stops the nuclear translocation of NF-AT (nuclear factor of activated T-cells), blocking the transcription of Interleukin-2 (IL-2) and related cytokines. Consequently, T-lymphocyte activation, mast cell reactivity, and eosinophil migration are reduced, resolving allergic skin inflammation at the source.

Clinical Indications

IndicationClinical Presentation & BenefitCanine Atopic Dermatitis (CAD)Relieves chronic itching, paw chewing, ventral redness, and recurrent allergic flare-upsChronic Allergic PruritusControls refractory skin allergies caused by environmental allergens (pollen, dust mites, mold)Perianal Fistulas (Anal Furunculosis)Aids in resolving deep, ulcerative perianal lesions and reduces chronic inflammationImmune-Mediated DermatosesAdjuvant or maintenance therapy for auto-reactive skin conditions (e.g., pemphigus foliaceus)

Dosage & Administration Guidelines

Administer strictly in accordance with your veterinarian’s prescription.

• Target Therapeutic Dose: The standard starting dose is 5 mg per kg body weight once daily administered orally (e.g., one 50 mg capsule daily for a 10 kg dog).

• Administration Timing: For maximum and consistent absorption, administer the capsule on an empty stomach—either at least 1 hour before or 2 hours after a meal. (If stomach upset occurs, discuss with your vet about giving with a small treat or freezing the capsules briefly prior to dosing).

• Treatment Timeline & Tapering: Clinical improvement is typically visible within 3 to 4 weeks. Once symptoms are controlled (usually within 4–8 weeks), your veterinarian may taper the frequency to alternate days or twice weekly to find the minimal effective maintenance dose.

• Do Not Stop Abruptly: Discontinuing therapy suddenly can cause a rapid resurgence of severe itching and inflammation.

Product Specifications

AttributeDetailsBrandVivaldis Animal HealthActive StrengthCyclosporine 50 mgDosage FormSoft Gelatin Oral CapsulesPack SizeStrip of 5 CapsulesTarget SpeciesDogs OnlyPrescription StatusSchedule H Prescription Medicine (Valid Rx mandatory on PetMitra)

Contraindications & Safety Precautions

• Neoplasia & Malignancies: Do not administer to dogs with a history of malignant disorders or progressive neoplasia.

• Active Infections: Do not begin therapy in dogs with untreated systemic fungal or severe bacterial infections until the infection has cleared.

• Minimum Age/Weight: Not recommended for puppies under 6 months of age or dogs weighing less than 2 kg.

• Vaccination Notice: Inactivated vaccines are preferred; avoid administering live attenuated vaccines immediately before or during treatment.

• Mild Side Effects: Mild vomiting, loose stools, or transient lethargy may occur during the first 7–10 days; these usually resolve spontaneously.

• Storage: Store below 25°C in a dry place. Protect from moisture and direct sunlight. Keep out of reach of children and household pets