Intas Aventix 112.5mg Long-Acting Systemic Ectoparasiticide Chewable Tablet for Toy Breed Dogs & Puppies (2kg to 4.5kg) – Fluralaner 112.5mg (Single Chewable Tablet Pack)

Active Formulation Matrix & Pharmacological Actions

Active ConstituentStrengthChemical & Pharmacological ClassParasite Targets & Mode of ActionFluralaner112.5 mgIsoxazoline Systemic Insecticide & AcaricideAntagonizes arthropod GABA-gated & L-glutamate-gated chloride channels; induces fatal neuronal hyperexcitation in Fleas (Ctenocephalides), Ticks (Rhipicephalus, Ixodes, Dermacentor), and Mites (Demodex, Sarcoptes, Otodectes).Chewable Excipient BaseBase q.s. to 1 Chewable TabletFlavored Oral Treat MatrixEnsures high voluntary oral acceptance, rapid gastric disintegration, and optimal systemic bioavailability when co-administered with meals.

Clinical Veterinary Indications

• Treatment and long-term prevention of flea infestations (Ctenocephalides felis and Ctenocephalides canis) for 12 weeks.

• Treatment and control of tick infestations (Rhipicephalus sanguineus, Ixodes ricinus, Dermacentor reticulatus) for 12 weeks.

• Prevention of tick-borne hemoparasitic transmission (Babesia canis, Ehrlichia canis, Hepatozoon).

• Therapeutic control and maintenance of Flea Allergy Dermatitis (FAD).

• Treatment and resolution of Generalized Demodicosis (Demodex canis).

• Treatment and cure of Sarcoptic Mange (Sarcoptes scabiei var. canis).

• Treatment and control of ear mite infestations (Otodectes cynotis).

Comparison: Intas Aventix 112.5mg vs. Monthly Oral Isoxazolines vs. Toy-Dog Spot-Ons

Feature / MetricIntas Aventix 112.5mg (Current)Monthly Isoxazolines (e.g., NexGard 11.3mg / Simparica 5mg)Toy-Dog Fipronil Spot-On PipetteActive MoleculeFluralaner (112.5 mg)Afoxolaner / SarolanerFipronil + S-MethopreneDuration of Protection12 Weeks (3 Full Months per dose)4 Weeks (Requires strict monthly dosing)3 to 4 WeeksDosing Frequency per YearOnly 4 doses per year12 doses per year12 monthly topical applicationsRisk of Protection LapsesExtremely Low (Single chew covers 90 days)Moderate (Frequently forgotten monthly dates)Moderate to HighWater / Grooming Resistance100% Waterproof (Systemic oral)100% Waterproof (Systemic oral)Diminished by frequent grooming bathsTarget Weight Band2.0 kg to 4.5 kg Toy Dogs1.3–2.5 kg / 2.5–5 kg bandedUp to 4.5 kg pipette

Complete Intas Aventix Weight-Dosing Spectrum

Aventix VariantFluralaner StrengthTarget Canine Body Weight BandCommon Representative BreedsAventix Toy (Current)112.5 mg2.0 kg to 4.5 kgChihuahuas, Pomeranians, Yorkshire Terriers, Toy Poodles, MalteseAventix Small250 mg4.5 kg to 10 kgShih Tzus, Pugs, Lhasa Apsos, DachshundsAventix Medium500 mg10 kg to 20 kgBeagles, Cocker Spaniels, French Bulldogs, IndiesAventix Large1000 mg20 kg to 40 kgLabradors, Golden Retrievers, German ShepherdsAventix Giant1400 mg40 kg to 56 kgRottweilers, Great Danes, Saint Bernards, Mastiffs

Directions for Use & Administration Protocol

For oral administration in dogs only under direct veterinary prescription:

1. Verify Exact Body Weight: Confirm that your dog weighs between 2.0 kg and 4.5 kg on a calibrated veterinary scale prior to administration.

2. Administer with Meals (Mandatory): Always give Aventix with or immediately following a regular meal. Dietary fats significantly enhance the intestinal absorption and systemic bioavailability of fluralaner.

3. Feeding Technique: Offer the miniature chewable tablet directly from your hand like a treat. If your toy dog is a picky eater, place it directly into a small portion of wet food, boiled chicken, or paneer.

4. Monitor Ingestion: Observe your dog for several minutes to verify that the tablet is chewed and swallowed completely. Never divide or break tablets to split doses across multiple dogs.

5. Re-Treatment Interval: Administer one tablet once every 12 weeks (every 3 months) for continuous, year-round defense against ticks, fleas, and mites.

Product Specifications

ParameterDetailsBrandIntas Pharmaceuticals Ltd. (Intas Animal Health - PET Division)Product Trade NameAventix Fluralaner Chewable Tablet (112.5mg)Product ClassificationLong-Acting Systemic Veterinary Isoxazoline EctoparasiticideActive CompositionFluralaner (112.5 mg per chewable tablet)Dosage FormFlavored Soft Chewable Oral TabletPackaging SizeUnit Pack of 1 Chewable TabletTarget SpeciesDogs Only (Weighing 2.0 kg to 4.5 kg; 6 months of age and older)Therapeutic ClassSystemic Insecticide & Acaricide / Anti-Tick, Flea & Mange TreatmentPrescription StatusSchedule H / Veterinary Prescription Medicine (Rx required)

Safety Warnings, Precautions & Contraindications

• CANINE USE ONLY (STRICTLY CONTRAINDICATED IN CATS): Formulated and dosed exclusively for dogs. Do not administer to cats under any circumstances.

• Age & Weight Parameters: Safe for puppies and dogs 6 months of age and older weighing at least 2.0 kg. Do not administer to puppies under 8 weeks of age or dogs weighing less than 2.0 kg.

• Neurological Precaution: Isoxazoline-class medications have occasionally been associated with neurological adverse reactions (tremors, ataxia, seizures). Use with clinical caution in dogs with a documented history of seizure disorders or idiopathic epilepsy.

• Parasite Feeding Requirement: Ectoparasites must attach and begin feeding on the dog to absorb fluralaner; brief tick attachment prior to mortality may occur.

• Reproductive Safety: Validated safe for use in breeding, pregnant, and lactating female dogs.

• Adverse Reactions: Well tolerated overall. In rare instances, mild, self-limiting gastrointestinal signs (vomiting, soft stools, transient inappetence) may occur shortly after ingestion.

• Storage: Store below 30°C in a dry place protected from heat and direct sunlight. Keep the blister pack sealed until immediately prior to administration. Keep strictly out of reach of children and domestic pets.