Intas Aventix 1400mg Long-Acting Systemic Ectoparasiticide Chewable Tablet for Extra Large & Giant Dogs (40kg to 56kg) – Fluralaner 1400mg (Single Chewable Tablet Pack)

Active Formulation Matrix & Pharmacological Actions

Active IngredientStrengthChemical & Pharmacological ClassTarget Parasites & Biological Mode of ActionFluralaner1400.0 mgIsoxazoline Systemic Insecticide & AcaricideSelectively blocks parasite neuronal GABA-gated & L-glutamate-gated chloride channels; induces fatal neural hyperexcitation in Fleas (Ctenocephalides), Ticks (Rhipicephalus, Ixodes, Dermacentor), and Mites (Demodex, Sarcoptes, Otodectes).Palatable Chewable BaseBase q.s. to 1 Chewable TabletFlavored Oral Treat MatrixEnsures high voluntary acceptance, rapid gastric disintegration, and optimal systemic bioavailability when dosed with food.

Clinical Veterinary Indications

• Treatment and long-term prevention of flea infestations (Ctenocephalides felis and Ctenocephalides canis) for 12 weeks.

• Treatment and control of tick infestations (Rhipicephalus sanguineus, Ixodes ricinus, Dermacentor reticulatus) for 12 weeks.

• Reducing the risk of tick-borne disease transmission (Babesia canis, Ehrlichia canis, Lyme disease).

• Strategic therapeutic management of Flea Allergy Dermatitis (FAD).

• Treatment and clinical cure of Generalized Demodicosis (Demodex canis).

• Treatment and clinical cure of Sarcoptic Mange (Sarcoptes scabiei var. canis).

• Treatment of ear mite infestations (Otodectes cynotis).

Comparison: Intas Aventix (Fluralaner) vs. Monthly Oral Isoxazolines vs. Monthly Spot-Ons

Feature / MetricIntas Aventix 1400mg (Current)Monthly Isoxazolines (e.g., Afoxolaner / Sarolaner)Topical Monthly Spot-On (Fipronil)Active DrugFluralaner (1400 mg)Afoxolaner / SarolanerFipronil + S-MethopreneDuration of Protection12 Weeks (3 Full Months per dose)4 Weeks (Requires monthly re-dosing)3 to 4 WeeksDosing Frequency per YearOnly 4 doses per year12 doses per year12 monthly applicationsRisk of Protection GapsExtremely Low (Single tablet covers 90 days)Moderate (Easily forgotten monthly dates)Moderate to HighBath & Water Resistance100% Unaffected (Systemic oral)100% Unaffected (Systemic oral)Degraded by frequent bathing or swimmingTarget Weight Range40 kg to 56 kg Giant DogsWeight-banded monthly chewsUp to 40 kg per pipette

Complete Intas Aventix Weight-Dosing Spectrum

Aventix VariantFluralaner ContentTarget Canine Body Weight BandRepresentative BreedsAventix Toy112.5 mg2.0 kg to 4.5 kgChihuahuas, Pomeranians, Yorkshire TerriersAventix Small250 mg4.5 kg to 10 kgShih Tzus, Pugs, Lhasa Apsos, Toy PoodlesAventix Medium500 mg10 kg to 20 kgBeagles, Cocker Spaniels, French Bulldogs, IndiesAventix Large1000 mg20 kg to 40 kgLabradors, Boxers, Dalmatians, DobermansAventix Giant (Current)1400 mg40 kg to 56 kgRottweilers, German Shepherds, Great Danes, Mastiffs

Note: For dogs weighing over 56 kg, veterinarians typically administer an appropriate combination of two tablets (e.g., 1400mg + 250mg) to match exact body weight.

Directions for Use & Administration Protocol

For oral administration in dogs only under direct veterinary prescription:

1. Weight Verification: Accurately weigh your dog on a digital scale to ensure body weight falls within the 40 kg to 56 kg band.

2. Administration with Food (Crucial Step): Always administer Aventix with or around the time of feeding. The presence of dietary lipids in the stomach significantly enhances the systemic bioavailability and intestinal absorption of fluralaner.

3. Voluntary Acceptance: Offer the chewable tablet directly by hand as a treat. Most dogs accept it eagerly due to its savory flavor profile. Alternatively, mix the tablet whole into a small portion of wet dog food or meat.

4. Complete Dose Assurance: Observe the dog for a few minutes to confirm the chewable tablet is chewed and swallowed completely. Do not break or crush the tablet unless directed by your veterinarian.

5. Re-Treatment Interval: Administer one tablet once every 12 weeks (every 3 months) for continuous, year-round protection against ticks, fleas, and mites.

Product Specifications

ParameterDetailsBrandIntas Pharmaceuticals Ltd. (Intas Animal Health - PET Division)Product Trade NameAventix Fluralaner Chewable Tablet (1400mg)Product ClassificationLong-Acting Systemic Veterinary Isoxazoline EctoparasiticideActive CompositionFluralaner (1400 mg per chewable tablet)Dosage FormFlavored Soft Chewable Oral TabletPackaging SizeUnit Pack of 1 Chewable TabletTarget SpeciesDogs Only (Weighing 40 kg to 56 kg; 6 months of age and older)Therapeutic ClassSystemic Insecticide & Acaricide / Anti-Tick, Flea & Mange TreatmentPrescription StatusSchedule H / Veterinary Prescription Medicine (Rx required)

Safety Warnings, Precautions & Contraindications

• CANINE USE ONLY (STRICTLY CONTRAINDICATED IN CATS): Formulated and dosed exclusively for dogs. Do not administer to cats under any circumstances.

• Age & Weight Parameters: Safe for puppies and dogs 6 months of age and older weighing at least 2 kg. Do not administer this 1400mg strength to dogs weighing under 40 kg.

• Seizure Precaution: Isoxazoline-class medications have occasionally been associated with neurological adverse events (muscle tremors, ataxia, seizures). Use with clinical caution in dogs with a pre-existing history of seizure disorders or idiopathic epilepsy.

• Parasite Attachment Note: Parasites must begin feeding on the host dog to become exposed to fluralaner. Therefore, the brief attachment of ticks prior to mortality cannot be completely ruled out.

• Reproductive Safety: Validated safe for use in breeding, pregnant, and lactating female dogs.

• Adverse Reactions: Well tolerated overall. In rare instances, mild, transient gastrointestinal reactions (vomiting, reduced appetite, diarrhea, salivation) may occur shortly after dosing.

• Storage: Store below 30°C in a dry place protected from heat and direct sunlight. Keep the blister sealed until immediately prior to administration. Keep strictly out of reach of children and domestic pets.