Intas Nayflee Plus Dual-Action Spot-On Solution for Dogs

Active Pharmaceutical Matrix & Pharmacological Actions

Active ConstituentConcentration (% w/v)Pharmacological ClassTarget Parasites & Biological Mode of ActionFipronil IP9.8% w/vPhenylpyrazole EctoparasiticideBlocks insect neuronal GABA-gated & glutamate-gated chloride channels; triggers fatal neural hyperexcitation in adult Ticks (Rhipicephalus, Ixodes, Dermacentor), Fleas (Ctenocephalides), and Lice (Trichodectes canis).(S)-Methoprene IP8.8% w/vInsect Growth Regulator (IGR) / Juvenile Hormone MimicPenetrates flea eggshells and larval cuticles; disrupts embryonic development and arrests metamorphosis, rendering flea eggs and larvae non-viable.Spreading VehicleBase q.s. to pipette volumeLipid-Translocating BaseEnhances capillary spreading along epidermal lipid films and facilitates storage in sebaceous glands.

Clinical Veterinary Indications

• Treatment, control, and monthly prevention of tick infestations (Rhipicephalus sanguineus, Ixodes ricinus, Dermacentor reticulatus).

• Comprehensive elimination and prevention of flea infestations (Ctenocephalides canis, Ctenocephalides felis).

• Environmental flea population suppression by preventing the development of eggs, larvae, and pupae.

• Strategic therapeutic management of Flea Allergy Dermatitis (FAD).

• Elimination of biting lice (Trichodectes canis).

• Supportive control of sarcoptic mange mites (Sarcoptes scabiei var. canis) under veterinary supervision.

Weight-Banded Product Portfolio

Intas Nayflee Plus VariantPipette VolumeTarget Body Weight RangeRepresentative BreedsSmall Dogs0.67 mlUp to 10 kgShih Tzu, Pug, Pomeranian, Lhasa Apso, DachshundMedium Dogs1.34 ml10 kg to 20 kgBeagle, Cocker Spaniel, French Bulldog, Medium IndiesLarge Dogs2.68 ml20 kg to 40 kgLabrador, Golden Retriever, German Shepherd, BoxerExtra Large Dogs4.02 mlAbove 40 kgRottweiler, Great Dane, Saint Bernard, Mastiff

Comparison: Intas Nayflee Plus Spot-On vs. Nayflee Spray vs. Aventix Chews

Feature / ParameterIntas Nayflee Plus Spot-On (Current)Intas Nayflee SprayIntas Aventix Chewable TabletActive CompositionFipronil + (S)-MethopreneFipronil (0.25%) aloneFluralaner (Isoxazoline)Insect Growth Regulator (IGR)Yes (Kills eggs & larvae)No (Adults only)No (Adult speed-of-kill stops oviposition)Application FormatTopical spot-on pipetteWhole-body pump sprayOral chewable treatDuration of ProtectionUp to 30 days (1 month)Up to 30 days12 Weeks (3 full months)Minimum Age Requirement8 weeks (min 2 kg)Safe under 8 weeks6 months (min 2 kg)Feline Cross-SafetyUse canine pipettes for dogs only (separate cat pipette exists)Safe for both dogs & catsContraindicated in cats

Directions for Use & Step-by-Step Application Protocol

For topical spot-on cutaneous application on dogs only:

The 48-Hour Bathing Rule (Crucial for Efficacy):

Do not bathe your dog for 48 hours before and 48 hours after application. The formulation relies on natural skin sebum to spread across the body. Bathing immediately before strips these oils, while bathing immediately after washes the active ingredients off before they enter the sebaceous glands.

Step-by-Step Application Instructions:

1. Remove Pipette: Hold the pipette upright and snap off the top along the scored line (or snip the tip with clean scissors).

2. Expose the Skin: With your dog standing, part the coat at the base of the neck between the shoulder blades until the skin is clearly visible. (Applying between the shoulder blades prevents the dog from turning around to lick the application site).

3. Apply Directly to Skin: Place the tip of the pipette directly onto the bare skin and squeeze firmly several times to empty the entire contents in one or two spots.

4. Avoid Fur Saturation: Apply directly to the skin surface rather than saturating the fur to prevent runoff.

5. Multi-Spot Application for Large Dogs: For dogs weighing over 20 kg (2.68 ml or 4.02 ml pipettes), divide the volume evenly across 2 to 3 spots along the dorsal midline from the shoulder blades to the base of the tail.

6. Air-Dry: Allow the application site to dry naturally. A temporary wet or oily sheen at the application site is normal and resolves within 24 hours.

Product Specifications

ParameterDetailsBrandIntas Pharmaceuticals Ltd. (NUVO Division - Animal Health)Product Trade NameNayflee Plus Spot-On for DogsProduct ClassificationDual-Action Broad-Spectrum Veterinary Topical EctoparasiticideActive CompositionFipronil IP (9.8% w/v) + (S)-Methoprene IP (8.8% w/v)Dosage FormClear Topical Spot-On SolutionPackaging SizeSingle Pipette in Blister Pack (0.67ml / 1.34ml / 2.68ml / 4.02ml)Target SpeciesDogs Only (8 weeks of age and older, minimum 2 kg body weight)Therapeutic ClassAdulticide + Insect Growth Regulator (IGR) / Anti-Tick, Flea & Lice PipettePrescription StatusOTC Veterinary Ectoparasitic Formulation (No Rx required)

Safety Warnings, Precautions & Contraindications

• CANINE-SPECIFIC PIPETTE (DO NOT USE ON CATS): These pipettes are formulated and dosed specifically for dogs. Do not apply canine pipettes to cats (use dedicated Intas Nayflee Plus for Cats pipettes instead).

• Prevent Ingestion & Licking: Avoid application in areas where the dog can reach to lick. Ingestion can cause transient hypersalivation (frothing at the mouth) and mild nausea due to the bitter alcohol base. Keep treated dogs separated until the application site is completely dry to prevent mutual grooming.

• Age & Weight Parameters: Do not use on puppies under 8 weeks of age or dogs weighing less than 2 kg. For younger puppies, use Intas Nayflee Fipronil Spray.

• Do Not Apply on Broken Skin: Do not apply over open wounds, raw scratch excoriations, or active skin infections.

• Storage: Store below 25°C in a cool, dry place protected from heat, sparks, and direct sunlight. Keep pipettes sealed in foil blister packaging until immediate use. Keep strictly out of reach of children and domestic pets.