Savavet Fiprofort Plus Dual-Action Spot-On Solution for Medium Dogs (10 to 20 kg) – Fipronil 9.8% w/v + (S)-Methoprene 8.8% w/v (1.34 ml Pipette)

Active Formulation Matrix & Pharmacological Modes of Action

Active ConstituentConcentrationChemical ClassPharmacological Mechanism & Clinical RoleFipronil9.8% w/vPhenylpyrazoleNon-systemic broad-spectrum insecticide/acaricide. Blocks insect GABA and GluCl channels, causing neuronal hyperexcitation and death in adult ectoparasites.(S)-Methoprene8.8% w/vJuvenile Hormone Analog (IGR)Insect Growth Regulator. Mimics juvenile hormone to prevent egg hatching, inhibit larval pupation, and break the environmental breeding cycle.Excipient Baseq.s. to 1.34 mlSebotropic Lipid VehicleEnables lateral migration across the cutaneous sebum film and deposition into sebaceous follicular reservoirs.

Target Parasite Spectrum & Residual Clinical Efficacy

Ectoparasite TypeSpecies CoveredResidual Protection WindowClinical SignificanceFleas (Adults)Ctenocephalides felis, Ctenocephalides canisUp to 60 to 90 Days (Re-apply monthly for active FAD)Kills adult fleas within 24 hours of contact before egg laying.Flea Eggs & LarvaeC. felis immature stagesUp to 8 to 12 WeeksArrests embryonic and larval development; eliminates environmental reservoirs.Ticks (All Stages)Rhipicephalus sanguineus, Ixodes spp., Dermacentor spp.Up to 30 Days (4 Weeks)Kills vectors of Babesiosis, Ehrlichiosis, and Anaplasmosis within 48 hours.Biting / Chewing LiceTrichodectes canisUp to 30 DaysClears adult lice and nymphs, relieving scaling and intense itching.Sarcoptic MangeSarcoptes scabiei var. canisMonthly application aidHelps control mite burdens as part of a multi-modal veterinary treatment plan.

Comparison: Savavet Fiprofort Plus vs. Regular Fiprofort (Fipronil Only) vs. Oral Isoxazolines

Feature / MetricFiprofort Plus Spot-On (1.34 ml)Regular Fipronil Spot-OnOral Isoxazoline Chews (Sarolaner / Fluralaner)Active IngredientsFipronil + (S)-MethopreneFipronil onlySingle-molecule isoxazolineFlea Life Cycle BreakYes (Kills adults + eggs + larvae)Partial (Kills adults only)Indirect (Kills adults before egg deposition)Mode of Parasite ContactExternal Cuticular Contact (No bite needed)External ContactSystemic (Parasite must take a blood meal)Action on Environmental FleasDirect (Kills eggs/larvae in bedding)NoneNoneAdministration RouteTopical spot-on (zero swallowing)Topical spot-onOral chewable ingestionSuitability for GI Sensitive DogsHigh (Bypasses stomach and liver)HighCan occasionally trigger vomiting or nauseaDosing FrequencyMonthly (Every 30 days)Monthly (Every 30 days)Monthly (or 3-monthly for Fluralaner)

Savavet Fiprofort Plus Weight-Tier Dosing Matrix

Pack PresentationNet VolumeTarget Dog Body Weight BracketTypical Breed ExamplesSmall Dogs / Puppies0.67 mlUp to 10 kgPug, Shih Tzu, Lhasa Apso, Pomeranian, Toy PoodleMedium Dogs [Current]1.34 ml10 kg to 20 kgBeagle, Cocker Spaniel, French Bulldog, Spitz, IndieLarge Dogs2.68 ml20 kg to 40 kgLabrador Retriever, Golden Retriever, German Shepherd, BoxerExtra Large Dogs4.02 ml40 kg to 60 kgRottweiler, Doberman, Great Dane, Saint Bernard, Mastiff

Step-by-Step Directions for Use & Application Protocol

For external topical application only on dogs weighing between 10 kg and 20 kg:

Application Steps:

1. Accurate Weighing: Confirm the dog's body weight is between 10 kg and 20 kg prior to application.

2. Pipette Preparation: Remove the 1.34 ml pipette from the blister pack. Hold it upright and tap the narrow neck to ensure all liquid settles into the main reservoir. Snap off the pre-scored tip along the contoured line.

3. Part the Fur (Crucial): Part the dog's coat at the base of the neck, between the shoulder blades, until the bare skin is clearly visible.

4. Direct Dermal Application: Place the pipette tip directly against the skin. Squeeze the bulb firmly several times to empty the entire 1.34 ml contents onto one or two spots directly on the skin.

5. Avoid Fur Saturation: Apply directly to the skin surface rather than the hair coat to prevent runoff and ensure proper absorption into the sebaceous layer.

6. Air-Drying: Allow the application site to dry naturally. Do not touch, rub, or brush the site until completely dry. Prevent other household pets from grooming the treated area for 4 to 6 hours.

The Mandatory 48-Hour Bathing Rule:

• Do NOT bathe or shampoo the dog within 48 hours prior to application.

• Do NOT bathe, shampoo, or let the dog swim within 48 hours following application.

• Clinical Reason: Bathing temporarily strips the natural sebum and lipid mantle from the skin, which is required for Fipronil and (S)-Methoprene to disperse across the body and anchor into sebaceous glands.

Product Specifications

ParameterDetailsBrandSavavet (Sava Healthcare Limited)Product Trade NameFiprofort Plus Spot-On Solution for Medium DogsActive IngredientsFipronil 9.8% w/v + (S)-Methoprene 8.8% w/vTherapeutic ClassEctoparasiticide (Phenylpyrazole + Insect Growth Regulator)Net Content1.34 ml Single-Dose PipetteTarget Species & WeightDogs weighing 10 kg to 20 kg Body WeightMinimum Age RequirementPuppies from 8 to 10 weeks of age (weighing at least 2 kg)Prescription StatusOTC Veterinary Ectoparasiticide (No Rx required)Shelf Life24 Months from Date of Manufacture

Safety Warnings, Precautions & Contraindications

• Strictly for Canine Use: While Fipronil can be used in cats, this specific Fiprofort Plus 1.34 ml pipette is calibrated exclusively for medium dogs. For feline patients, use species-specific Fiprofort Cat pipettes (0.5 ml).

• Absolute Contraindication in Rabbits: Never use on pet rabbits or small rodents. Fipronil can cause severe neurological collapse, convulsions, and high mortality in rabbits.

• Avoid Damaged Skin: Do not apply to open wounds, severe weeping eczema, or extensively lacerated skin.

• Transient Hypersalivation: If a dog accidentally licks the application site while wet, bitter excipients may cause temporary drooling or mild oral irritation. This is self-limiting; offering fresh drinking water will help clear the taste.

• Flammability Warning: Contains an alcoholic carrier. Keep away from heat, open flames, and electrical sparks until fully dry.

• Storage Instructions: Store below 30°C in a dry place away from heat and direct sunlight. Protect from freezing. Keep strictly out of reach of children and domestic animals.