Savavet Fiprofort Plus Master Portfolio – Dual-Action Ectoparasitic Spot-On Solution for Dogs

Active Formulation Matrix & Pharmacological Actions

Active ConstituentConcentrationPharmacological ClassPhysiological Target & Mode of ActionFipronil9.8% w/vPhenylpyrazoleBroad-spectrum contact adulticide. Inhibits insect GABA and GluCl channels, causing neuronal hyper-excitation and death in adult fleas, ticks, and lice.(S)-Methoprene8.8% w/vJuvenile Hormone Analog (IGR)Insect Growth Regulator. Mimics juvenile hormone to prevent egg hatching and inhibit larval-to-pupal metamorphosis in home environments.Sebotropic Excipientsq.s.Lipid Diffusion VehicleFacilitates lateral spreading across the cutaneous sebum film and deposition into sebaceous follicular reservoirs.

Target Parasite Spectrum & Residual Clinical Efficacy

Ectoparasite TypeSpecies CoveredProtection WindowClinical Threat & Pathology PreventedAdult FleasCtenocephalides felis, Ctenocephalides canisUp to 60–90 Days (Re-apply monthly for active FAD)Severe Flea Allergy Dermatitis (FAD), secondary superficial pyoderma, and Dipylidium caninum tapeworm.Flea Eggs & LarvaeImmature Ctenocephalides life stagesUp to 12 Weeks (84 Days)Clears microscopic environmental reservoirs from home carpets, rugs, and bedding.Ticks (All Stages)Rhipicephalus sanguineus, Ixodes spp., Haemaphysalis spp.Up to 30 Days (1 Month)Vectors of Canine Babesiosis, Canine Monocytic Ehrlichiosis, Anaplasmosis, and Tick Paralysis.Biting / Chewing LiceTrichodectes canisUp to 30 DaysClears adult lice and nits, relieving scaling, matted fur, and intense scratching.Sarcoptic Mange (Aid)Sarcoptes scabiei var. canisMonthly application aidSupplementary topical aid for clearing burrowing scabies mites under veterinary direction.

Complete Weight-Tier Pipette Dosing Guide

Pack VariantNet VolumeTarget Dog Body WeightRepresentative Breed ExamplesFiprofort Plus Small Dog0.67 mlUp to 10 kgPug, Shih Tzu, Lhasa Apso, Pomeranian, Chihuahua, Maltese, Toy PoodleFiprofort Plus Medium Dog1.34 ml10 kg to 20 kgBeagle, Cocker Spaniel, French Bulldog, Indian Pariah Dog (Medium), SpitzFiprofort Plus Large Dog2.68 ml20 kg to 40 kgLabrador Retriever, Golden Retriever, German Shepherd, Boxer, DobermanFiprofort Plus Extra Large4.02 ml40 kg to 60 kgRottweiler, Great Dane, Saint Bernard, Bullmastiff, Tibetan Mastiff

Step-by-Step Directions for Use & Application Protocol

Strictly for external topical application on dogs and puppies from 8 weeks of age:

Application Steps:

1. Weigh Accurately: Match the pipette size strictly to your dog's current body weight; never guess or approximate.

2. Pipette Preparation: Remove the pipette from the blister packaging. Hold it upright facing away from your face and tap the narrow neck so all liquid flows into the main chamber. Snap off the tip along the pre-scored breakline.

3. Part the Fur (Crucial): Part the dog's coat at the back of the neck between the shoulder blades until bare skin is clearly visible.

4. Direct Dermal Application: Place the pipette tip directly onto the skin surface. Squeeze the pipette firmly several times to empty the entire contents onto one or two spots directly on the skin.

5. Avoid Fur Saturation: Apply directly to the skin rather than the outer hair to prevent runoff and ensure proper absorption into the sebaceous layer.

6. Air-Drying & Multi-Pet Management: Allow the treated spot to air-dry naturally. Do not touch, rub, or brush the site until completely dry. Keep treated dogs separated from other household pets for 4 to 6 hours to prevent mutual licking or grooming.

The Mandatory 48-Hour Bathing Rule:

• Do NOT bathe or shampoo the dog within 48 hours prior to application.

• Do NOT bathe, shampoo, or let the dog swim within 48 hours following application.

• Clinical Reason: Soap and water strip the epidermal lipid film required for Fipronil and (S)-Methoprene to disperse across the body and embed into sebaceous glands. Plan baths around the application schedule.

Comparison: Savavet Fiprofort Plus vs. Regular Fipronil vs. Oral Isoxazolines

Clinical FeatureSavavet Fiprofort Plus (Current)Regular Fipronil Spot-OnOral Chewables (Sarolaner / Fluralaner)Active CompositionFipronil + (S)-Methoprene (IGR)Fipronil OnlySingle-Molecule IsoxazolineFlea Life Cycle BreakDirect (Kills adults + eggs + larvae)Partial (Kills adults only)Indirect (Kills adults before egg laying)Mode of Parasite KillCuticular Contact (No bite required)Cuticular ContactSystemic (Parasite must take a blood meal)Action on Home InfestationDirectly sterilizes eggs in beddingNoneNoneAdministration RouteTopical spot-on (zero swallowing)Topical spot-onOral chewable ingestionSuitability for GI Sensitive DogsHigh (Bypasses stomach and liver)HighCan occasionally cause vomiting or nauseaDosing FrequencyMonthly (Every 30 days)Monthly (Every 30 days)Monthly (or 3-monthly for Fluralaner)

Product Specifications

ParameterDetailsBrandSavavet (Sava Healthcare Limited)Product Trade NameFiprofort Plus Spot-On Solution for DogsActive IngredientsFipronil 9.8% w/v + (S)-Methoprene 8.8% w/vTherapeutic ClassificationEctoparasiticide (Phenylpyrazole + Insect Growth Regulator)Packaging PresentationSingle-Dose Pipettes (0.67 ml, 1.34 ml, 2.68 ml, 4.02 ml)Target SpeciesDogs Only (from 8 weeks of age and minimum 2 kg body weight)Target ParasitesTicks, Adult Fleas, Flea Eggs/Larvae, Chewing LiceProtection Duration1 Month (30 Days) per PipettePrescription StatusOTC Veterinary Ectoparasiticide Formulation (No Rx required)Shelf Life24 Months from Date of Manufacture

Safety Warnings, Precautions & Contraindications

• STRICT CANINE SPECIFICITY: Do NOT use this canine formulation on cats. Dogs and cats require different concentrations of active ingredients; always use Savavet Fiprofort Plus for Cats (0.5 ml) for feline pets.

• ABSOLUTE CONTRAINDICATION IN RABBITS: Never use on pet rabbits or small rodents. Fipronil can cause severe neurological collapse, convulsions, and high mortality in lagomorphs.

• Damaged Skin: Do not apply directly onto open cuts, weeping lesions, or severe ulcerated wounds.

• Transient Hypersalivation: If a dog licks the application site while wet, bitter excipients may cause temporary drooling or mild agitation. This is an adverse taste reaction, not systemic toxicity; providing clean drinking water helps clear the taste.

• Flammability Warning: Contains an alcoholic carrier. Keep away from open flames, heat sources, and sparks until completely dry.

• Storage Instructions: Store below 30°C in a dry place away from heat and direct sunlight. Protect from freezing. Keep strictly out of reach of children and domestic pets.