Savavet Fondatone (Mometasone Furoate 0.1% w/v) Medicated Topical Corticosteroid Lotion for Dogs & Cats

Active Formulation Matrix & Pharmacological Actions

ParameterSpecificationPharmacological Mechanism & Clinical RoleActive Pharmaceutical IngredientMometasone Furoate (0.1% w/v / 1 mg/ml)High-potency, synthetic chlorinated glucocorticosteroid.Pharmacological ClassTopical Anti-Inflammatory & Antipruritic CorticosteroidSuppresses dermal phospholipase $A_2$ and downregulates NF-$\kappa$B inflammatory gene transcription.Vehicle / Formulation BaseSoothing Non-Greasy Lotion BaseFacilitates trans-epidermal penetration without clumping fur or leaving oily residues.Tissue SelectivityHigh Dermal Affinity & LipophilicityBinds to epidermal glucocorticoid receptors with minimal systemic vascular spillover.Metabolic EliminationRapid Hepatic BiotransformationAny trace absorbed systemically is metabolized by hepatic cytochrome P450 enzymes into inactive polar metabolites.

Clinical Veterinary Indications

• Canine Atopic Dermatitis (CAD): Symptomatic control of localized allergic skin flares, groin/axillary erythema, and pruritus.

• Flea Allergy Dermatitis (FAD): Soothes dorsal-lumbar hypersensitivity papules, crusts, and itching.

• Acute Moist Dermatitis ("Hot Spots"): Dries and calms superficial weeping, erosive pyotraumatic plaques.

• Allergic Contact Dermatitis: Eases inflammation triggered by lawn grasses, carpet fibers, shampoos, or floor chemicals.

• Interdigital Pododermatitis: Manages localized inflammation, redness, and swelling between canine paw pads.

• Adjuvant Otitis Externa: Reduces canal wall erythema, edema, and hyperplasia when paired with an indicated antibiotic or antifungal agent.

Comparison: Savavet Fondatone (Mometasone) vs. Hydrocortisone vs. Betamethasone

Clinical ParameterSavavet Fondatone (Mometasone 0.1%)Hydrocortisone (0.5%–1.0%)Betamethasone Dipropionate (0.05%–0.1%)Topical Potency ClassHigh PotencyMild / Low PotencyHigh / Very High PotencyDuration of ActionLong-acting (Typically Once Daily)Short-acting (Requires 2–3 applications/day)Long-actingSystemic HPA Suppression RiskLow (Rapidly metabolized systemically)Very LowModerate to HighSkin Thinning (Atrophy) RiskLow with short-to-medium coursesMinimalHigh with prolonged useApplication FormatNon-Greasy Topical Lotion SprayCreams & PowdersOintments & Drops

Directions for Use & Step-by-Step Application Protocol

Strictly for external topical application on dogs and cats under direct veterinary direction:

Application Steps:

1. Clean & Dry the Area: Gently cleanse the affected skin patch using a mild, non-irritating antiseptic wash or clean saline. Pat dry with sterile gauze before application.

2. Expose the Skin: Part the pet's hair coat carefully over the lesion so the skin surface is clearly visible. If the hair is heavily matted over a "hot spot," trim the surrounding fur with blunt-ended scissors.

3. Application:

   • Direct Spray: Hold the bottle 5 to 10 cm away and spray a light mist directly onto the affected skin.

   • Sensitive Areas (Near Eyes/Ears): Spray Fondatone onto clean cotton or a gloved fingertip and dab gently onto the skin.

4. Thin Film Application: Apply as a thin, uniform film. Do NOT bandage, wrap, or occlude the site, as occlusive dressings can substantially increase systemic corticosteroid absorption.

5. Prevent Licking (Crucial 15–20 Minute Window): Divert the pet's attention (with a chew toy, treat puzzle, or leash walk) or fit an Elizabethan collar (E-collar) for 15 to 20 minutes while the lotion fully dries to prevent oral ingestion.

6. Wash Hands: Thoroughly clean hands with soap and water following application.

Recommended Dosing Frequency & Duration:

• Standard Frequency: Apply a thin layer to affected areas once daily (q24h), or as directed by your prescribing veterinarian.

• Duration: Typically prescribed for an initial course of 5 to 14 consecutive days. Do not discontinue abruptly if used on large areas over extended periods; follow your veterinarian's tapering guidance.

Product Specifications

ParameterDetailsBrandSavavet (Sava Healthcare Limited)Product Trade NameFondatone Topical LotionActive MoleculeMometasone Furoate 0.1% w/v (1 mg/ml)Therapeutic ClassificationTopical Glucocorticosteroid / Medicated Dermatological SolutionNet Volume30 ml Spray BottleTarget SpeciesDogs and CatsPrescription StatusPrescription Veterinary Medicine (Rx Required)Packaging TypeDispensing bottle fitted with a metered fine-mist spray pump

Contraindications, Safety Warnings & Precautions

• Untreated Infectious Skin Conditions: Do NOT apply to active bacterial, viral, or fungal infections without concurrent antimicrobial therapy. Corticosteroids suppress local immune responses and can allow unchecked microbial proliferation.

• Ruptured Tympanic Membrane Warning: When using as an otic anti-inflammatory, verify tympanic membrane (eardrum) integrity first. Do not use in ears with a ruptured eardrum.

• Avoid Ophthalmic Contact: Strictly avoid contact with the eyes. Do not use in animals with corneal ulcers.

• Prolonged Use Precaution: Avoid long-term continuous use over large body surface areas to prevent localized skin thinning (atrophy), alopecia, delayed wound healing, or systemic adrenal axis suppression.

• Pregnancy & Lactation: Use during pregnancy or lactation only if explicitly evaluated and authorized by the attending veterinarian.

• Storage Instructions: Store at room temperature (below 30°C) away from direct heat, moisture, and sunlight. Keep the bottle tightly capped. Keep strictly out of reach of children and animals.