Savavet Nulura (Fluralaner 1400 mg) Chewable Ectoparasitic Tablet for Extra Large & Giant Breed Dogs (40 to 56 kg)

Active Formulation Matrix & Pharmacological Parameters

Pharmacological ParameterClinical SpecificationMode of Action & SignificanceActive SubstanceFluralaner (1400 mg)Systemic synthetic isoxazoline insecticide and acaricide.Target Weight BracketExtra Large Dogs (40.0 kg to 56.0 kg)Delivers 25 mg to 35 mg Fluralaner per kg body weight.Target Neural ChannelsInsect GABA & Glutamate-gated Cl⁻ ChannelsPotent dual antagonist action causes spastic neuromuscular paralysis and death in arthropods.Speed of Kill (Fleas)Within 8 Hours of AttachmentPrevents oviposition; flea population crashes in the home environment.Speed of Kill (Ticks)Within 12 Hours of AttachmentIntercepts vector transmission pathways for hemoparasitic protozoa and rickettsiae.Duration of Efficacy12 Weeks (84 Days / 3 Months)Long terminal half-life provides sustained protection without monthly dosing gaps.Bioavailability & AbsorptionEnhanced by Co-Administration with FoodAdministration at or around mealtime significantly improves oral absorption and systemic bioavailability.

Ectoparasite Spectrum & Targeted Pathogens

Parasite GroupSpecies TargetedClinical Vector Threat & Condition PreventedTicks (Acarids)Rhipicephalus sanguineus (Brown Dog Tick), Ixodes spp., Dermacentor spp., Haemaphysalis spp.Canine Babesiosis (Babesia gibsoni/canis), Canine Monocytic Ehrlichiosis (E. canis), Anaplasmosis, Tick Paralysis.Fleas (Insects)Ctenocephalides felis (Cat Flea), Ctenocephalides canis (Dog Flea)Severe Flea Allergy Dermatitis (FAD), secondary superficial pyoderma, Dipylidium caninum (tapeworm) infestation.Mites (Acarids)Demodex canis, Sarcoptes scabiei var. canis, Otodectes cynotisGeneralized demodicosis, sarcoptic mange (scabies), severe pruritus, crusting, and secondary ear mite otitis.

Comparison: Savavet Nulura (Fluralaner 1400 mg) vs. Simparica (Sarolaner 120 mg) vs. NexGard (Afoxolaner 136 mg)

Clinical FeatureSavavet Nulura (Fluralaner 1400 mg) [Current]Simparica (Sarolaner 120 mg)NexGard (Afoxolaner 136 mg)Active MoleculeFluralanerSarolanerAfoxolanerTarget Weight40 kg to 56 kg40 kg to 60 kg25 kg to 50 kgProtection DurationFull 12 Weeks (3 Months / 84 Days)4 Weeks (1 Month / 30 Days)4 Weeks (1 Month / 30 Days)Dosing Frequency4 Doses per Year12 Doses per Year12 Doses per YearFlea Kill SpeedWithin 8 HoursWithin 8 HoursWithin 8 HoursTick Kill SpeedWithin 12 HoursWithin 12 HoursWithin 24–48 HoursBathing / Water Impact100% Water-Fast (Systemic)100% Water-Fast (Systemic)100% Water-Fast (Systemic)Compliance AdvantageHighest (Eliminates monthly dosing lapse)Requires strict monthly adherenceRequires strict monthly adherence

Directions for Use & Administration Protocol

For oral administration only in dogs weighing 40 kg to 56 kg:

Dosage Schedule:

• Administer 1 chewable tablet of Savavet Nulura 1400 mg once every 12 weeks (3 months).

• Mealtime Administration (Critical): Administer the chewable tablet at or around the time of feeding. Co-administration with food substantially enhances the gastrointestinal absorption and systemic bioavailability of Fluralaner.

• For dogs weighing over 56 kg: Use an appropriate combination of two tablets that most closely matches the body weight under veterinary direction.

Administration Tips:

1. Direct Acceptance: Formulated as a palatable flavored chew; most giant breeds take it voluntarily from your hand or food bowl like a treat.

2. Alternative Method: If not accepted voluntarily, it can be enclosed in a ball of wet food or placed gently on the base of the tongue for normal swallowing.

3. Do Not Crush or Split: Do not break or divide the tablet; the 1400 mg tablet must be administered whole to ensure the full therapeutic dose is delivered.

4. Treatment Timing: Can be initiated at any time of the year; for continuous protection, repeat administration every 12 weeks without interruption.

Savavet Nulura (Fluralaner) Complete Weight-Tier Lineup

Pack PresentationFluralaner StrengthTarget Dog Body Weight BracketNulura Very Small Dogs112.5 mg2 kg to 4.5 kgNulura Small Dogs250 mg4.5 kg to 10 kgNulura Medium Dogs500 mg10 kg to 20 kgNulura Large Dogs1000 mg20 kg to 40 kgNulura Extra Large Dogs [Current]1400 mg40 kg to 56 kg

Product Specifications

ParameterDetailsBrandSavavet (Sava Healthcare Limited)Product Trade NameNulura Chewable Tablets for Extra Large DogsActive IngredientFluralaner 1400 mg per tabletTherapeutic ClassificationSystemic Insecticide and Acaricide (Isoxazoline Class)Target Weight RangeExtra Large & Giant Dogs (40.0 kg to 56.0 kg Body Weight)Onset of Action8 Hours for Fleas; 12 Hours for TicksProtection Window12 Weeks (3 Months / 84 Days)FormOral Flavored Chewable TabletPackaging SizeSingle Tablet Blister Pack (1 Tablet per Box)Prescription StatusVeterinary Prescription Medicine (Rx Required)

Safety Warnings, Precautions & Contraindications

• Host Attachment Notice: Fleas and ticks must attach to the host and begin feeding to be exposed to systemic Fluralaner. While onset is rapid (8–12 hours), the risk of parasite-borne disease transmission cannot be entirely excluded if attachment occurs.

• Neurological Class Precaution: Isoxazolines (including Fluralaner, Sarolaner, and Afoxolaner) have been associated with adverse neurological events such as muscle tremors, ataxia, and seizures in rare cases. Use with caution in dogs with a pre-existing history of epilepsy or seizure disorders.

• Body Weight Verification: Ensure the dog weighs at least 40 kg before administering this 1400 mg tablet. For dogs under 40 kg, choose the corresponding lower strength (112.5 mg, 250 mg, 500 mg, or 1000 mg).

• Breeding & Pregnancy Safety: Fluralaner has demonstrated a wide safety profile and can be used in breeding, pregnant, and lactating female dogs under veterinary supervision.

• Storage Instructions: Store in the original package at room temperature (below 30°C). Protect from moisture and direct sunlight. Keep strictly out of reach of children and domestic animals.