Savavet Nulura (Fluralaner 250 mg) Chewable Ectoparasitic Tablet for Small Dogs (4.5 to 10 kg)

• Selective Arthropod GABA & Glutamate-Gated Chloride Channel Blockade: Fluralaner is a next-generation isoxazoline with high selective affinity for arthropod neuronal receptors over mammalian channels. Once ingested, Fluralaner binds to circulating plasma proteins and distributes into systemic tissue fluid. As soon as a tick or flea commences feeding, the active molecule selectively blocks insect $\gamma$-aminobutyric acid (GABA)-gated and L-glutamate-gated chloride channels. This triggers uncontrolled neuronal hyperexcitation, spastic paralysis, and rapid parasite mortality.

• Rapid Clinical Onset of Action:

  • Fleas: Onset of killing efficacy starts within 8 hours of attachment. Adult fleas are eliminated before they can mate and deposit viable eggs, breaking the flea lifecycle and clearing indoor environmental contamination.

  • Ticks: Onset of killing efficacy starts within 12 hours of attachment. Rapid neutralization dramatically reduces the transmission window for tick-borne hemoparasites (Babesia and Ehrlichia typically require 24 to 48 hours of sustained feeding to transmit infective sporozoites into host circulation).

• Extended 12-Week Duration of Action (3 Months): Fluralaner possesses a long plasma elimination half-life and slow metabolic clearance, maintaining therapeutic systemic blood levels for 84 full days. A single tablet provides 3 times the duration of protection of standard monthly oral chews (such as Afoxolaner or Sarolaner).

• Effective Demodectic & Sarcoptic Mange Clearance: Systemic capillary distribution delivers active acaricidal concentrations directly to hair follicles and deeper cutaneous layers, successfully clearing stubborn Demodex canis (demodectic mange), Sarcoptes scabiei (scabies), and Otodectes cynotis (ear mites).

• Palatable Chewable Presentation: Formulated as a soft, highly palatable flavored chew that small dogs accept voluntarily as a treat, eliminating the mess, skin irritation, and water-washout limitations of topical spot-on treatments.

Key Features

• Active Fluralaner 250 mg: Potent isoxazoline systemic ectoparasiticide.

• Calibrated for Small Dogs (4.5–10 kg): Formulated specifically for small breeds (Pugs, Shih Tzus, Lhasa Apsos, Dachshunds, Cavalier King Charles Spaniels).

• Full 3 Months (12 Weeks) Protection: Provides unbroken tick and flea defense from a single oral tablet.

• Rapid Kill Speed: Kills fleas within 8 hours and ticks within 12 hours of attachment.

• Breaks the Flea Life Cycle: Kills adult fleas before egg production, controlling home infestations.

• Acaricidal Action on Mange: Highly effective therapy for Demodectic, Sarcoptic, and Ear Mite infestations.

• Reduces Hemoparasite Risks: Fast kill time significantly lowers the risk of Babesia and Ehrlichia transmission.

• Water-Proof & Bath-Proof: Because it works systemically, swimming, routine shampooing, or rainy walks do not diminish efficacy.

• Stress-Free Oral Administration: Palatable chewable tablet administered easily with food.

Full Detail

Active Formulation Matrix & Pharmacological Parameters

Pharmacological ParameterClinical SpecificationMode of Action & SignificanceActive SubstanceFluralaner (250 mg)Systemic synthetic isoxazoline insecticide and acaricide.Target Weight BracketSmall Dogs (4.5 kg to 10.0 kg)Delivers 25 mg to 55.5 mg Fluralaner per kg body weight.Target Neural ChannelsInsect GABA & Glutamate-gated Cl⁻ ChannelsPotent dual antagonist action causes spastic neuromuscular paralysis and death in arthropods.Speed of Kill (Fleas)Within 8 Hours of AttachmentPrevents oviposition; flea population crashes in the home environment.Speed of Kill (Ticks)Within 12 Hours of AttachmentIntercepts vector transmission pathways for hemoparasitic protozoa and rickettsiae.Duration of Efficacy12 Weeks (84 Days / 3 Months)Long terminal half-life provides sustained protection without monthly dosing gaps.Bioavailability & AbsorptionEnhanced by Co-Administration with FoodAdministration at or around mealtime significantly improves oral absorption and systemic bioavailability.

Ectoparasite Spectrum & Targeted Pathogens

Parasite GroupSpecies TargetedClinical Vector Threat & Condition PreventedTicks (Acarids)Rhipicephalus sanguineus (Brown Dog Tick), Ixodes spp., Dermacentor spp., Haemaphysalis spp.Canine Babesiosis (Babesia gibsoni/canis), Canine Monocytic Ehrlichiosis (E. canis), Anaplasmosis, Tick Paralysis.Fleas (Insects)Ctenocephalides felis (Cat Flea), Ctenocephalides canis (Dog Flea)Severe Flea Allergy Dermatitis (FAD), secondary superficial pyoderma, Dipylidium caninum (tapeworm) infestation.Mites (Acarids)Demodex canis, Sarcoptes scabiei var. canis, Otodectes cynotisGeneralized demodicosis, sarcoptic mange (scabies), severe pruritus, crusting, and secondary ear mite otitis.

Comparison: Savavet Nulura (Fluralaner 250 mg) vs. Simparica (Sarolaner 20 mg) vs. NexGard (Afoxolaner 28.3 mg)

Clinical FeatureSavavet Nulura (Fluralaner 250 mg) [Current]Simparica (Sarolaner 20 mg)NexGard (Afoxolaner 28.3 mg)Active MoleculeFluralanerSarolanerAfoxolanerTarget Weight4.5 kg to 10 kg5 kg to 10 kg4 kg to 10 kgProtection DurationFull 12 Weeks (3 Months / 84 Days)4 Weeks (1 Month / 30 Days)4 Weeks (1 Month / 30 Days)Dosing Frequency4 Doses per Year12 Doses per Year12 Doses per YearFlea Kill SpeedWithin 8 HoursWithin 8 HoursWithin 8 HoursTick Kill SpeedWithin 12 HoursWithin 12 HoursWithin 24–48 HoursBathing / Water Impact100% Water-Fast (Systemic)100% Water-Fast (Systemic)100% Water-Fast (Systemic)Compliance AdvantageHighest (Eliminates monthly dosing lapse)Requires strict monthly adherenceRequires strict monthly adherence

Directions for Use & Administration Protocol

For oral administration only in dogs weighing 4.5 kg to 10 kg:

Dosage Schedule:

• Administer 1 chewable tablet of Savavet Nulura 250 mg once every 12 weeks (3 months).

• Mealtime Administration (Critical): Administer the chewable tablet at or around the time of feeding. Co-administration with food substantially enhances the gastrointestinal absorption and systemic bioavailability of Fluralaner.

Administration Tips:

1. Direct Acceptance: Formulated as a palatable flavored chew; most small dogs accept it voluntarily from your hand or food bowl like a treat.

2. Alternative Method: If the dog does not accept the tablet voluntarily, it can be hidden in a small portion of wet dog food or placed directly toward the back of the tongue for gentle swallowing.

3. Do Not Crush or Split: Do not break or divide the tablet; the 250 mg tablet must be administered whole to ensure the full therapeutic dose is delivered.

4. Treatment Timing: Can be initiated at any time of the year; for continuous protection, repeat administration every 12 weeks without interruption.

Savavet Nulura (Fluralaner) Complete Weight-Tier Lineup

Pack PresentationFluralaner StrengthTarget Dog Body Weight BracketNulura Very Small Dogs112.5 mg2 kg to 4.5 kgNulura Small Dogs [Current]250 mg4.5 kg to 10 kgNulura Medium Dogs500 mg10 kg to 20 kgNulura Large Dogs1000 mg20 kg to 40 kgNulura Extra Large Dogs1400 mg40 kg to 56 kg

Product Specifications

ParameterDetailsBrandSavavet (Sava Healthcare Limited)Product Trade NameNulura Chewable Tablets for Small DogsActive IngredientFluralaner 250 mg per tabletTherapeutic ClassificationSystemic Insecticide and Acaricide (Isoxazoline Class)Target Weight RangeSmall Dogs (4.5 kg to 10.0 kg Body Weight)Onset of Action8 Hours for Fleas; 12 Hours for TicksProtection Window12 Weeks (3 Months / 84 Days)FormOral Flavored Chewable TabletPackaging SizeSingle Tablet Blister Pack (1 Tablet per Box)Prescription StatusVeterinary Prescription Medicine (Rx Required)

Safety Warnings, Precautions & Contraindications

• Host Attachment Notice: Fleas and ticks must attach to the host and begin feeding to be exposed to systemic Fluralaner. While onset is rapid (8–12 hours), the risk of parasite-borne disease transmission cannot be entirely excluded if attachment occurs.

• Neurological Class Precaution: Isoxazolines (including Fluralaner, Sarolaner, and Afoxolaner) have been associated with adverse neurological events such as muscle tremors, ataxia, and seizures in rare cases. Use with caution in dogs with a pre-existing history of epilepsy or seizure disorders.

• Puppy Age & Weight Restrictions: Do not use in puppies younger than 8 weeks of age or dogs weighing less than 2 kg. For dogs under 4.5 kg, use the 112.5 mg strength.

• Breeding & Pregnancy Safety: Fluralaner has demonstrated a wide safety profile and can be used in breeding, pregnant, and lactating female dogs under veterinary supervision.

• Storage Instructions: Store in the original package at room temperature (below 30°C). Protect from moisture and direct sunlight. Keep strictly out of reach of children and domestic animals.