Savavet K-Pet (Ketoconazole IP 200mg) Antifungal Tablets for Dogs & Cats (Strip of 10 Tablets)

Active Pharmaceutical Ingredient & Pharmacological Profile

• Active Composition: Each uncoated tablet contains Ketoconazole IP – 200 mg.

• Drug Class: Synthetic Imidazole Derivative / Systemic Antifungal Agent.

• Pharmacokinetics & Mechanism:

  • Absorption: Ketoconazole is lipophilic and requires an acidic gastric environment for optimal gastrointestinal dissolution and systemic bioavailability. Administering with food significantly improves absorption and minimizes gastric upset.

  • Distribution: High affinity for keratinized tissues, sebum, skin layers, and liver, delivering concentrated therapeutic levels straight to infected dermal structures and hair shafts.

  • Metabolism & Excretion: Extensively metabolized by hepatic enzymes and predominantly excreted via bile into the feces.

Target Clinical Indications

Clinical CategoryTarget PathogensClinical PresentationYeast Dermatitis & OtitisMalassezia pachydermatisGreasy, hyperpigmented skin, rancid odor, chronic foot licking, and swollen nail foldsDermatophytosis (Ringworm)Microsporum canis, M. gypseum, Trichophyton mentagrophytesCircular patches of alopecia, broken hair stubs, scaling epidermal collarettesSystemic MycosesBlastomyces, Histoplasma, Coccidioides, CryptococcusDeep granulomatous skin lesions, lymphadenopathy, systemic fungal disseminationEndocrine Management (Off-label)Adrenal Cortical HyperplasiaPituitary-dependent Cushing's Disease (due to inhibition of adrenal cortisol synthesis)

Dosage & Administration Guidelines

Administer orally strictly under the supervision and prescription of a qualified veterinarian. Accurate weighing of your pet prior to starting therapy is essential.

• General Veterinary Dose Range:

  • Dogs: Typically 5 mg to 10 mg per kg body weight, administered once daily or split into two doses (every 12 hours).

  • Cats: Typically 5 mg to 10 mg per kg body weight once daily (use with close veterinary monitoring due to species-specific hepatic sensitivity).

• Administration Instructions:

  1. Administer with Meals: Always give K-Pet with or immediately after a meal (especially a fat-containing food). Food enhances drug absorption and protects against nausea.

  2. Do Not Crush Prematurely: Offer the tablet whole concealed in a treat or wet food, or split along the score line for precise weight-based fractions.

  3. Treatment Duration: Fungal therapies require patience. Superficial yeast infections usually require 2 to 4 weeks; dermatophytosis (ringworm) typically requires treatment until two consecutive fungal cultures or Wood's lamp tests return negative (often 4 to 8 weeks).

Product Specifications & Suitability

ParameterDetailsBrandSavavet (Sava Healthcare Ltd.)Generic NameKetoconazole Tablets IP 200mgProduct Trade NameK-PetDosage FormOral Scored TabletsPack SizeStrip of 10 Tablets (Box of 1 x 10 or 10 x 10 Tablets)Target SpeciesDogs & CatsTherapeutic ClassPrescription Veterinary Systemic AntifungalPrescription StatusPrescription Medicine (Rx Required)

Safety Warnings, Contraindications & Precautions

• Prescription Only (Rx): Must be administered strictly in accordance with veterinary advice and dosage calculation.

• Hepatic Monitoring: Ketoconazole is metabolized in the liver. Baseline liver enzyme profiles (ALT, ALP) and periodic monitoring are strongly recommended for long-term courses. Do not use in pets with pre-existing acute hepatic impairment.

• Pregnancy & Lactation: Contraindicated in pregnant or breeding animals due to known teratogenic and embryotoxic risks.

• Drug Interactions: Ketoconazole is a potent inhibitor of Cytochrome P450 (CYP3A) enzymes. It significantly increases blood levels of cyclosporine, methylprednisolone, and digoxin. Do not administer concurrently with antacids, H2 blockers, or proton pump inhibitors (omeprazole), as reduced stomach acid prevents ketoconazole absorption.

• Potential Side Effects: Transient loss of appetite (anorexia), vomiting, or soft stools may occur. If persistent nausea or jaundice develops, pause medication and consult your veterinarian immediately.

• Storage: Store below 25°C in a dry place protected from moisture and direct sunlight. Keep out of reach of children and household pets.