Savavet Toxo-Mox (Amoxicillin Trihydrate IP + Potassium Clavulanate IP) Potentiated Broad-Spectrum Antibacterial Tablets for Dogs & Cats (Pack of 10 Tablets)

Active Pharmaceutical Profile & Clinical Mechanism

Active ConstituentPharmacological ClassPhysiological Mode of Action & Antimicrobial TargetsAmoxicillin Trihydrate IPAminopenicillin (Beta-Lactam Antibiotic)Binds to bacterial penicillin-binding proteins (PBPs), inhibiting transpeptidase enzymes and halting peptidoglycan cell wall cross-linking. Causes osmotic lysis in susceptible gram-positive and gram-negative bacteria.Potassium Clavulanate IPBeta-Lactamase InhibitorIrreversibly binds and inactivates bacterial beta-lactamase enzymes, shielding amoxicillin from hydrolysis and overcoming acquired bacterial resistance.ExcipientsOral Tablet MatrixStabilized, compressed, scored tablet base designed for rapid gastric disintegration and consistent systemic bioavailability.

Clinical Indications

• Dermatology & Pyoderma: Superficial bacterial folliculitis, deep pyoderma, interdigital furunculosis, impetigo, and infected acute moist dermatitis ("hot spots") (Staphylococcus pseudintermedius).

• Soft Tissue & Wound Infections: Infected puncture wounds, bite lacerations, subcutaneous abscesses, and post-surgical site infections (Pasteurella multocida, Staphylococcus).

• Periodontal & Oral Infections: Gingivitis, periodontitis, alveolar bone abscesses, stomatitis, and oral ulcerations (Bacteroides, Fusobacterium, Streptococcus).

• Urinary Tract Infections (UTIs): Acute and recurrent bacterial cystitis and pyelonephritis (E. coli, Proteus, Klebsiella).

• Respiratory Infections: Feline Upper Respiratory Infections (URI complications), tracheobronchitis (kennel cough), and bronchopneumonia.

• Bacteremia & Systemic Sepsis: Adjunctive bactericidal therapy in systemic bacterial bloodstream infections.

Dosage & Administration Guidelines

Administer orally twice daily (every 12 hours) strictly as directed by your veterinarian:

• Standard Therapeutic Dosage Rate: 12.5 mg to 25 mg total actives (Amoxicillin + Clavulanate) per kg body weight every 12 hours. (Standard clinical baseline is 13.75 mg/kg BID, titrated up to 20–25 mg/kg BID for deep pyoderma or severe urinary/respiratory infections).

Pet Body WeightToxo-Mox 250 mg TabletToxo-Mox 500 mg Tablet4 kg to 5 kg (Cat / Toy Dog)1/4 Tablet (approx. 62.5 mg) twice daily—9 kg to 10 kg (Small Dog)1/2 Tablet (125 mg) twice daily—18 kg to 20 kg (Medium Dog)1 Tablet (250 mg) twice daily1/2 Tablet (250 mg) twice daily36 kg to 40 kg (Large Dog)2 Tablets (500 mg) twice daily1 Tablet (500 mg) twice daily55 kg to 60 kg (Giant Dog)—1.5 Tablets (750 mg) twice daily

• Administration Instructions:

  • Can be given directly by mouth or hidden in a small treat or meal portion.

  • Give with Food: Administering with or immediately after a meal reduces the incidence of transient nausea or vomiting.

  • Feline Precaution: When administering solid tablets to cats, always follow immediately with a small syringe of water (3–5 ml) or a spoonful of wet food to ensure smooth esophageal transit.

• Course Duration:

  • Skin & Soft Tissue Infections: 5 to 7 days (continue for 48 hours past complete resolution of clinical signs).

  • Deep Pyoderma: 14 to 28 consecutive days as directed by your veterinarian.

  • Urinary Tract Infections: 10 to 14 consecutive days.

  • Complete the Full Course: Never stop treatment early even if visible symptoms clear, to prevent bacterial relapse and resistant strain selection.

Comparison: Toxo-Mox Tablets vs. Toxo-Mox Dry Syrup

ParameterToxo-Mox TabletsToxo-Mox Dry SyrupDosage FormScored Oral TabletsReconstitutable Powder for Oral SuspensionBest Suited ForAdult dogs, medium-to-large breeds, easy-to-pill petsPuppies, kittens, toy dogs, and pill-resistant catsDosing PrecisionScored in half/quarter tablet incrementsMilliliter precision using oral syringe or dropperStorage & StabilityStore below 25°C at room temperature (24-month shelf life)Reconstituted: Must refrigerate (2°C–8°C), discard after 7–10 daysAdministrationHand-fed, hidden in treats, or placed on back of tongueDrawn into syringe and given by mouth or mixed in food

Product Specifications

ParameterDetailsBrandSavavet (Sava Healthcare Limited)Product Trade NameToxo-Mox TabletsActive CompositionAmoxicillin Trihydrate IP + Potassium Clavulanate IP (250mg or 500mg)Dosage FormOral Scored TabletsPack Size1 Blister Strip x 10 TabletsTarget SpeciesDogs and CatsTherapeutic ClassPrescription Veterinary Antibiotic / Potentiated AminopenicillinPrescription StatusSchedule H Veterinary Prescription Medicine (Valid Rx required at PetMitra checkout)

Safety Warnings, Precautions & Contraindications

• Prescription Only: Administer strictly under veterinary prescription and direction.

• Contraindications: Do NOT use in animals with known hypersensitivity or anaphylactic allergies to penicillins, ampicillin, or cephalosporins.

• STRICT SPECIES RESTRICTION: Do NOT administer to rabbits, guinea pigs, hamsters, chinchillas, or other small hindgut herbivores. Penicillins disrupt normal cecal microflora in these species, causing fatal clostridial enterotoxemia.

• Pregnancy & Lactation: Use during pregnancy and lactation only under direct veterinary supervision after a risk-benefit assessment.

• Drug Interactions: Do not administer concurrently with bacteriostatic antibiotics (e.g., Doxypet/Doxycycline, Erythromycin), as bacteriostatic agents antagonize the bactericidal cell-wall activity of beta-lactams.

• Storage: Store below 25°C in a dry place. Protect from excessive heat, direct sunlight, and moisture. Keep unused tablet halves sealed in the blister strip and administer within 24 to 48 hours. Keep strictly out of reach of children and household pets.