Virbac Pronefra Palatable Oral Suspension for Dogs & Cats – Advanced 4-in-1 Renal Support

Active Ingredients & 4-in-1 Mode of Action

Active ConstituentFunctional TargetClinical Mechanism & Renal BenefitCalcium Carbonate & Magnesium CarbonateDietary Phosphorus ControlBinds intestinal phosphate from food, forming insoluble complexes that pass unabsorbed in the stool.ChitosanUremic Toxin BindingMarine biopolymer that acts as an intestinal sponge, binding circulating indoxyl sulfate and nitrogenous waste.Astragalus membranaceus ExtractRenal ArchitectureProvides bioactive polysaccharides that help reduce oxidative stress and inhibit renal interstitial fibrogenesis.Hydrolyzed Marine OligopeptidesVascular MaintenanceModulates vascular tone to support normal arterial and glomerular blood pressure.Hydrolyzed Poultry & Fish ProteinsPalatability EnhancerStimulates appetite and voluntary intake in nauseous or finicky CKD patients.

Clinical Indications

• Chronic Kidney Disease (CKD) stages 1 through 4 in cats and dogs (under IRIS guidelines).

• Adjunct dietary management for hyperphosphatemia.

• Uremic gastrointestinal symptoms (inappetence, mild nausea, bad breath/uremic fetor).

• Senior pets requiring daily renoprotective and microvascular support.

Dosage & Administration Guidelines

Administer orally twice daily with meals, or directly into the mouth using the provided graduated dosing syringe.

• Standard Dosing:

  • Cats: 1 ml per 4 kg body weight, administered twice daily with food.

  • Dogs: 1 ml per 5 kg body weight, administered twice daily with food.

• Administration Instructions:

  1. Shake vigorously before each use to ensure uniform suspension of active binders.

  2. Unscrew the cap, insert the dosing syringe into the bottle adaptor, and invert to draw the exact dose based on your pet’s weight.

  3. Mix the liquid into your pet's regular food (ideally a wet renal support diet) or deliver directly into the corner of the mouth immediately before or during mealtime.

  4. Rinse the syringe with clean water and dry thoroughly after each use.

• Note: Always provide free and constant access to clean, fresh drinking water.

Product Specifications

ParameterDetailsBrandVirbac Animal HealthProduct Trade NamePronefra Palatable Oral SuspensionAvailable Sizes60 ml Bottle & 180 ml Bottle (with dosing syringe)Therapeutic ClassChronic Kidney Disease (CKD) / Renoprotective Oral SuspensionTarget SpeciesCats and DogsPrescription StatusVeterinary Recommended Dietetic Complement (Rx / Vet Supervised)

Safety Warnings, Precautions & Storage

• For animal / veterinary oral administration only. Not for human consumption.

• Administration Timing: Pronefra is most effective when administered with or immediately around meals, as its primary phosphorus-binding mechanism depends on binding dietary food components in the gut.

• Monitoring: Periodic veterinary evaluations (blood urea nitrogen, serum creatinine, phosphorus, and calcium checks) should be conducted every 3–6 months to assess CKD progression.

• Storage: Store in a cool, dry place below 25°C. Avoid direct exposure to sunlight. Do not freeze. Keep the bottle tightly capped and out of reach of children and household pets.