Intas Izopet Systemic Triazole Antifungal Oral Solution for Dogs & Cats – Itraconazole IP 10mg/ml (100ml Dispensing Bottle with Calibrated Measuring Cap)

Active Pharmaceutical Matrix & Pharmacological Actions

Active ConstituentConcentration per mlPharmacological ClassTarget Pathogens & Antimicrobial MechanismItraconazole IP10.0 mg per mlSynthetic Triazole Systemic AntifungalInhibits fungal cytochrome P450 14α-demethylase (CYP51); blocks ergosterol synthesis; disrupts fungal cell membrane permeability; bactericidal/fungistatic against Dermatophytes (Microsporum, Trichophyton), Yeasts (Malassezia, Candida), and Systemic Mycoses (Blastomyces, Histoplasma, Aspergillus).Oral Solution BaseBase q.s. to 1.0 mlSolubilized Liquid VehicleFormulated to enhance gastrointestinal dissolution and steady trans-mucosal absorption.

Clinical Veterinary Indications

• Dermatophytosis (Ringworm): Generalized, multifocal, or refractory ringworm caused by Microsporum canis, Microsporum gypseum, or Trichophyton mentagrophytes in dogs and cats.

• Malassezia Dermatitis: Chronic, greasy, pruritic yeast dermatitis and paronychia resistant to topical therapy alone.

• Cutaneous & Mucocutaneous Candidiasis: Infections caused by susceptible Candida species.

• Deep & Systemic Mycoses: Clinical management of systemic blastomycosis, histoplasmosis, cryptococcosis, and fungal rhinitis/pneumonia (aspergillosis).

• Sporotrichosis & Subcutaneous Mycetomas: Under qualified veterinary specialist monitoring.

Comparison: Intas Izopet Solution vs. Ketoconazole vs. Fluconazole

Clinical ParameterIntas Izopet Solution (Current)Ketoconazole (Oral Tablets)Fluconazole (Oral Tablets / Syrup)Antifungal ClassTriazole (3rd Generation)Imidazole (1st Generation)TriazoleBioavailability FormHomogeneous 10mg/ml liquidSolid compressed tabletsTablets / liquidAffinity for Skin/KeratinExtremely High (Keratinophilic)ModerateLow (Hydrophilic, penetrates CSF/urine)Hepatotoxicity RiskLow to ModerateHigh (frequent liver enzyme elevations)LowFeline SuitabilityGold Standard for FelinesPoorly tolerated in cats; riskySafe in cats, but less lipophilic for skinPulse Dosing CapabilityExcellent (Due to skin accumulation)PoorLimited

Dosage & Administration Guidelines

Administer orally strictly as prescribed by your treating veterinarian based on your pet's body weight:

• Standard Veterinary Dosing Parameters (General Reference):

  • Therapeutic Range: Typically dosed at 5 mg to 10 mg Itraconazole per kg body weight (equivalent to 0.5 ml to 1.0 ml of Izopet per kg body weight) administered once daily (every 24 hours).

  • Standard Pulse-Dosing Protocol (Commonly Prescribed for Ringworm):

    • Week 1: Daily dosing (7 consecutive days)

    • Week 2: Rest week (No medication)

    • Week 3: Daily dosing (7 consecutive days)

    • Week 4: Rest week (No medication)

    • Week 5: Daily dosing (7 consecutive days)

      (Always adhere to the specific cycle prescribed by your veterinarian following fungal culture or Wood's lamp evaluation).

• Practical Volume-to-Weight Reference Chart (at 5 mg/kg standard dose = 0.5 ml / kg):

Pet Body WeightRecommended Daily Volume (0.5 ml/kg)Clinical Notes1.0 kg to 2.0 kg0.5 ml to 1.0 mlPediatric kittens & toy puppies3.0 kg to 5.0 kg1.5 ml to 2.5 mlAdult cats & small toy dogs6.0 kg to 10.0 kg3.0 ml to 5.0 mlSmall dogs (Pugs, Shih Tzus, Lhasa Apsos)15.0 kg to 20.0 kg7.5 ml to 10.0 mlMedium dogs (Beagles, Cocker Spaniels, Indies)Above 20.0 kgTitrated by veterinarian (or transition to oral capsules)Large breeds

• Administration Instructions:

  • Always administer with or immediately following a meal: Gastrointestinal absorption is significantly enhanced by the presence of food and gastric acidity.

  • Can be administered directly via oral syringe or mixed into a small portion of wet gravy food, boiled chicken, or fish.

  • Shake the bottle well before each administration.

  • TREATMENT DURATION WARNING: Continue therapy until clinical cure and negative fungal cultures are achieved (typically 3 to 6 weeks). Discontinuing prematurely allows fungal hyphae to repopulate.

Product Specifications

ParameterDetailsBrandIntas Pharmaceuticals Ltd. (Intas Animal Health)Product Trade NameIzopet Itraconazole Oral SolutionProduct ClassificationBroad-Spectrum Veterinary Triazole Antifungal Oral SolutionActive CompositionItraconazole IP (10 mg per ml)Dosage FormOral Liquid SolutionPackaging Size100 ml Bottle with Calibrated Measuring DeviceTarget SpeciesDogs, Cats, Puppies, and Kittens across all life stagesTherapeutic ClassAntimycotic / Systemic Ergosterol Synthesis InhibitorPrescription StatusSchedule H / Veterinary Prescription Medicine (Rx required)

Safety Warnings, Precautions & Contraindications

• Prescription Only (Rx): Schedule H systemic antifungal. Must be prescribed and monitored by a licensed veterinarian.

• Hepatic Monitoring & Contraindications: Contraindicated in pets with severe pre-existing hepatic impairment or active liver failure. In pets on extended therapy (>3 weeks), periodic monitoring of serum liver enzymes (ALT, AST, ALP) is recommended. Concomitant use of a hepatoprotective tonic like Intas Livotas Pet is frequently co-prescribed.

• Pregnancy & Lactation Contraindication: Do not use in pregnant or nursing animals. Itraconazole is teratogenic and embryotoxic in laboratory animal models and is excreted in maternal milk.

• Potential Adverse Reactions: Generally well tolerated. Mild, transient inappetence, vomiting, or loose stools may occur. If severe anorexia, continuous vomiting, or jaundice (yellowing of sclera/gums) develops, discontinue medication immediately and consult your veterinarian.

• Drug Interactions: As a potent cytochrome P450 inhibitor, itraconazole can alter the metabolism of concurrent drugs. Inform your veterinarian of all medications your pet is receiving (e.g., antacids, proton pump inhibitors reduce absorption; do not administer within 2 hours of antacids).

• Storage: Store below 25°C in a cool, dry place protected from heat, direct sunlight, and moisture. Keep the bottle tightly closed. Keep strictly out of reach of children and domestic pets.