Intas Marbomet 50mg Advanced Veterinary Fluoroquinolone Antibacterial Tablets for Small to Medium Dogs & Cats – Marbofloxacin 50mg (Blister Strip of 6 Tablets)

Active Pharmaceutical Matrix & Pharmacological Actions

Active ConstituentStrength per TabletPharmacological ClassTherapeutic Target & Biological Mode of ActionMarbofloxacin IP50.0 mgSynthetic 3rd-Generation Fluoroquinolone AntibacterialInhibits bacterial DNA gyrase (Topoisomerase II) and Topoisomerase IV; arrests DNA replication and repair; bactericidal against Gram(-) (E. coli, Pseudomonas, Proteus, Klebsiella, Pasteurella) and Gram(+) (Staphylococcus pseudintermedius).Tablet Excipient BaseBase q.s. to 1 Scored TabletCompressed Oral MatrixFormulated for uniform active distribution, rapid gastric disintegration, and predictable trans-mucosal absorption.

Clinical Veterinary Indications

• Skin & Soft-Tissue Infections: Deep pyoderma, furunculosis, feline subcutaneous abscesses (fight bites), cellulitis, and infected wound lacerations.

• Complicated Urinary Tract Infections (UTIs): Recurrent bacterial cystitis, pyelonephritis, and bacterial prostatitis caused by susceptible E. coli, Proteus, or Pseudomonas.

• Respiratory Tract Infections: Feline upper respiratory tract infections (secondary bacterial pneumonia) and canine infectious respiratory disease complex (bronchitis/pneumonia).

• Perioperative Surgical Coverage: Contaminated soft-tissue surgeries, bite wounds, and exploratory laparotomies under veterinary direction.

Comparison: Intas Marbomet 50mg vs. Marbomet 150mg vs. Enrofloxacin 50mg

ParameterIntas Marbomet 50mg (Current)Intas Marbomet 150mgGeneric Enrofloxacin 50mgTarget Weight BracketCats & Small/Medium Dogs (2.5 kg to 18 kg)Large & Giant Dogs (20 kg to 55 kg)Small dogs & catsActive MoleculeMarbofloxacin (50mg)Marbofloxacin (150mg)Enrofloxacin (50mg)Feline Retinal SafetyHigh Margin of Ocular SafetyHigh (Dose-dependent)Narrow (Risk of irreversible retinal blindness)Activity Against PseudomonasModerate to HighModerate to HighModerateKilling KineticsConcentration-Dependent ($C_{\max}/\text{MIC}$)Concentration-Dependent ($C_{\max}/\text{MIC}$)Concentration-DependentDosing FrequencyOnce Daily (SID)Once Daily (SID)Once Daily (SID) or Divided BID

Dosage & Administration Guidelines

Administer orally strictly under licensed veterinary prescription based on verified body weight:

• Standard Veterinary Dosing Parameters:

  • Standard Clinical Range: Typically dosed at 2.0 mg to 5.5 mg Marbofloxacin per kg body weight, administered once daily (every 24 hours).

  • In severe, deep-seated infections or confirmed Pseudomonas soft-tissue infections, veterinarians typically prescribe toward the higher end of the range (~5 mg/kg once daily).

• Weight-Based Dosing Reference Guide for Marbomet 50mg Tablets:

Pet Body Weight RangeTypical Daily Dosage (at ~2.75–5.0 mg/kg basis)Clinical Context2.5 kg to 5.0 kg1/4 Tablet once dailyAdult cats, toy dogs (Chihuahuas, Pomeranians, Shih Tzu pups)5.0 kg to 10.0 kg1/2 Tablet once dailyLarge cats, small dogs (Pugs, Lhasa Apsos, Dachshunds)10.0 kg to 18.0 kg1 Tablet once dailyMedium dogs (Beagles, Cocker Spaniels, French Bulldogs)Above 20.0 kgTransition to Marbomet 150mgLarge breeds (Labradors, Golden Retrievers, GSDs)

• Administration Instructions:

  • Administer directly into the mouth, or conceal inside a small portion of wet food or boiled meat.

  • Avoid Dairy at Dosing Time: Do not administer with milk, cheese, paneer, curd, or mineral supplements (Intacal Pet Max, Feritas Pet, or Minmate). Divalent and trivalent cations ($Ca^{2+}$, $Fe^{2+}$, $Mg^{2+}$) chelate marbofloxacin in the gut, substantially reducing systemic absorption.

  • COURSE COMPLETION (MANDATORY): Complete the full prescribed course (typically 5 to 10 days for standard UTIs/abscesses; 21 to 30 days for deep pyoderma). Stopping early when visible symptoms improve can foster resistant bacterial strains.

Product Specifications

ParameterDetailsBrandIntas Pharmaceuticals Ltd. (Intas Animal Health - PET Division)Product Trade NameMarbomet 50mg TabletsProduct ClassificationAdvanced Veterinary Fluoroquinolone Systemic AntibacterialActive CompositionMarbofloxacin IP (50 mg per tablet)Dosage FormScored Compressed Oral TabletsPackaging SizeBlister Strip of 6 TabletsTarget SpeciesCats and Dogs (Under strict veterinary prescription)Therapeutic ClassSystemic Antibacterial / DNA-Gyrase InhibitorPrescription StatusSchedule H / Veterinary Prescription Medicine (Rx required)

Safety Warnings, Precautions & Contraindications

• Prescription Only (Rx): Schedule H antibacterial. Must be dispensed and administered under veterinary diagnosis, ideally supported by bacterial culture and sensitivity testing.

• Rapid Growth & Cartilage Precaution (Canines): Fluoroquinolones carry a documented risk of causing articular cartilage erosions and arthropathies in rapidly growing puppies. Contraindicated in puppies under 8 months of age (or under 12 to 18 months in large breeds) whose epiphyseal growth plates remain open.

• Central Nervous System Precaution: Use with caution in pets with a diagnosed history of epilepsy, severe hepatic encephalopathy, or active seizure disorders, as fluoroquinolones may lower the seizure threshold.

• Gastrointestinal Tolerability: Mild, self-limiting digestive signs (soft stools, reduced appetite, transient vomiting) may occasionally occur. Giving the tablet with a light, non-dairy meal reduces digestive sensitivity.

• Probiotic Spacing: When administering concurrent probiotics (such as Intas ZooLac Propaste or Guts-Up), separate doses by at least 2 to 3 hours to prevent antibiotic inactivation of the live beneficial flora.

• Storage: Store below 25°C in a dry place protected from heat, direct sunlight, and moisture. Keep tablets sealed in their original blister foil until administration. Keep strictly out of reach of children and domestic pets.